{"id":"W2800569219","doi":"10.1016/j.stem.2018.03.022","title":"The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment","year":2018,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Ontario Institute for Regenerative Medicine; Muscular Dystrophy Canada; University of Ottawa; Stem Cell Network; French Muscular Dystrophy Association; Advanced Foods and Materials Canada; Muscular Dystrophy Association","keywords":"Biology; MYF5; Cell biology; Stem cell; Epigenetics; Molecular biology; Transcription factor; Dystrophin; Myogenic regulatory factors; Skeletal muscle; MyoD; Myocyte; Myogenesis; Genetics; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002232791,0.0001934583,0.0001564124,0.0000174079,0.0004106209,0.00002220525,0.000453171,0.0001417974,0.00004630246],"category_scores_gemma":[0.000002416437,0.0001234127,0.0001106388,0.00008971741,0.0003996977,0.000003559813,0.0001667645,0.00009972639,0.00003969218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001466866,"about_ca_system_score_gemma":0.00004923706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004786345,"about_ca_topic_score_gemma":0.0000247613,"domain_scores_codex":[0.9987331,0.0002166448,0.0002932231,0.0003210042,0.0001380452,0.0002980087],"domain_scores_gemma":[0.9987926,0.00006595669,0.0002434675,0.0007390956,0.0001043259,0.00005449187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000153303,0.00011736,0.00007850248,0.00005045881,0.00001722685,2.229813e-7,0.0001771319,0.0001262756,0.9921518,0.00003658535,0.003103025,0.003988115],"study_design_scores_gemma":[0.000559276,0.0005734065,0.002951402,0.000008045878,0.00001837646,3.808381e-7,0.0007615413,0.0001788329,0.956071,0.0001314538,0.03859862,0.0001477152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989614,0.001181419,0.0003480232,0.0001867392,0.0001533706,0.0005321494,0.00001054698,0.00001116698,0.007962625],"genre_scores_gemma":[0.9966062,0.0001577222,0.00006971923,0.0001498633,0.0001487844,0.0000429374,0.00004244627,0.00002347509,0.002758906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03608084,"threshold_uncertainty_score":0.5032625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351816413781056,"score_gpt":0.2201363386282446,"score_spread":0.206618174490434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}