{"id":"W2800569219","doi":"10.1016/j.stem.2018.03.022","title":"The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment","year":2018,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":142,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; Canada Research Chairs; National Institutes of Health; Ontario Institute for Regenerative Medicine; Muscular Dystrophy Canada; University of Ottawa; Stem Cell Network; French Muscular Dystrophy Association; Advanced Foods and Materials Canada; Muscular Dystrophy Association","keywords":"Biology; MYF5; Cell biology; Stem cell; Epigenetics; Molecular biology; Transcription factor; Dystrophin; Myogenic regulatory factors; Skeletal muscle; MyoD; Myocyte; Myogenesis; Genetics; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001326694,0.0001629989,0.0001601075,0.000223275,0.0002744829,0.0005582075,0.0002080356,0.0002634003,0.002307661],"category_scores_gemma":[0.0002282713,0.0001765279,0.000171754,0.0001405487,0.0003069221,0.0002780341,0.000599477,0.0005022883,0.0005310749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004573189,"about_ca_system_score_gemma":0.0002124907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008236223,"about_ca_topic_score_gemma":0.002367134,"domain_scores_codex":[0.9998395,0.00002014102,0.000007474719,0.00005009307,0.00004380184,0.00003895902],"domain_scores_gemma":[0.9999036,0.00001513974,0.00002830939,0.00001399086,0.00001547356,0.00002358497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005943393,0.000006497445,0.0007098201,0.00001544092,0.000007408457,0.00005669975,0.00004340676,0.00006716152,0.9946849,0.00120514,0.0001266039,0.003017492],"study_design_scores_gemma":[0.00001711052,0.0000857225,0.04439772,0.00001722947,0.00002970117,0.0002093478,0.000160404,0.001847818,0.943671,0.0006716676,0.008878628,0.00001363712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801694,0.004628093,0.007367127,0.0003409837,0.0001280639,0.00001925269,0.0003458688,0.0001576919,0.006843657],"genre_scores_gemma":[0.9942952,0.0005854444,0.0007378126,0.00006623407,0.00001129208,0.000009146933,0.0001542931,0.00004375388,0.00409695],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002307661,"threshold_uncertainty_score":0.007719874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01351816413781056,"score_gpt":0.2201363386282446,"score_spread":0.206618174490434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}