{"id":"W2800645590","doi":"10.1007/s12022-018-9529-4","title":"Fit-for-Purpose Immunohistochemical Biomarkers","year":2018,"lang":"en","type":"review","venue":"Endocrine Pathology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Health Authority; University of Saskatchewan","funders":"","keywords":"Immunohistochemistry; Medicine; Pathology; Quality assurance; Companion diagnostic; Biomarker; Medical physics; Internal medicine; Cancer; Biology; External quality assessment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001503363,0.001008469,0.001420377,0.002613225,0.0002855457,0.001683087,0.001584478,0.001538951,0.005937584],"category_scores_gemma":[0.003795808,0.0003871276,0.0008661283,0.001628063,0.0007101044,0.002507327,0.001155251,0.001812515,0.003136213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008119881,"about_ca_system_score_gemma":0.001493966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008149166,"about_ca_topic_score_gemma":0.00205677,"domain_scores_codex":[0.9993419,0.00011116,0.0001193132,0.0001139114,0.0002370155,0.00007655039],"domain_scores_gemma":[0.9984623,0.0007685903,0.0002235026,0.00007817461,0.0003768562,0.00009058336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007294248,0.00003819178,0.001079817,0.007824183,0.0001138257,0.0004236342,0.0000297544,0.0002189735,0.000973187,0.001999566,0.05631795,0.9309081],"study_design_scores_gemma":[0.00002229091,0.0000527778,0.001559949,0.00758252,0.0003368757,0.003885713,0.00006012291,0.000150295,0.000856337,0.002496438,0.9829679,0.00002867734],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000297405,0.9930965,0.000821663,0.001352658,0.0009413784,0.00002858176,0.0001483869,0.00005365667,0.003259759],"genre_scores_gemma":[0.00442045,0.9858437,0.002008603,0.003157147,0.001058112,0.00003562247,0.0005635681,0.00001768306,0.00289514],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005937584,"threshold_uncertainty_score":0.01986319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07837462604614741,"score_gpt":0.4062226470612881,"score_spread":0.3278480210151407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}