{"id":"W2800649167","doi":"10.1161/circulationaha.118.034710","title":"Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins","year":2018,"lang":"en","type":"article","venue":"Circulation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Medicines Company; Alnylam Pharmaceuticals","keywords":"PCSK9; Medicine; Kexin; Proprotein convertase; LDL receptor; Ldl cholesterol; Cholesterol; Pharmacology; Lipoprotein; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001959733,0.00008614094,0.00008264079,0.00002094955,0.00004844243,0.000008721808,0.00009032321,0.00008922796,0.00004629514],"category_scores_gemma":[0.00004069388,0.00006683323,0.00005548083,0.00005152548,0.0000416832,0.000004430108,0.00001489874,0.00003226398,0.00002951754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007569703,"about_ca_system_score_gemma":0.00001779642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001189137,"about_ca_topic_score_gemma":0.00001106388,"domain_scores_codex":[0.9994152,0.00009121124,0.0001213194,0.000187557,0.00008069094,0.0001040027],"domain_scores_gemma":[0.9996116,0.000008214563,0.0000680291,0.0002230708,0.00006243985,0.00002670164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002395601,0.00002620464,0.002901189,0.00001083189,0.00002686936,4.038552e-7,0.00005232904,0.00007784585,0.9582888,0.00001320177,0.00001517669,0.03834754],"study_design_scores_gemma":[0.0002804282,0.002619997,0.01247908,0.00001498166,0.00001544202,0.000002921837,0.00001160722,0.000832425,0.9832793,0.00003872317,0.0003379948,0.00008713803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983999,0.0001218805,0.0008576412,0.000007584535,0.0001001363,0.0001518135,0.000002237995,0.000009083004,0.0003497851],"genre_scores_gemma":[0.9994124,0.000007517157,0.00004169966,0.00007812813,0.000341475,0.000008876243,0.00005263037,0.00001281883,0.00004450292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0382604,"threshold_uncertainty_score":0.272538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102677052122319,"score_gpt":0.2717787119014702,"score_spread":0.2615110066892383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}