{"id":"W2800649167","doi":"10.1161/circulationaha.118.034710","title":"Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins","year":2018,"lang":"en","type":"article","venue":"Circulation","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Medicines Company; Alnylam Pharmaceuticals","keywords":"PCSK9; Medicine; Kexin; Proprotein convertase; LDL receptor; Ldl cholesterol; Cholesterol; Pharmacology; Lipoprotein; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004416329,0.0004982454,0.0008405941,0.0003201441,0.0001732011,0.0004618693,0.0002669442,0.0006868545,0.004908801],"category_scores_gemma":[0.0004333393,0.0001951223,0.0004821837,0.0001459289,0.0003148459,0.0002692688,0.0002052805,0.0008499313,0.0005107438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003106141,"about_ca_system_score_gemma":0.0003719458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004389445,"about_ca_topic_score_gemma":0.001048277,"domain_scores_codex":[0.999801,0.00006041303,0.00002734341,0.00004443258,0.00003259968,0.00003423975],"domain_scores_gemma":[0.9998327,0.00005652481,0.00003811708,0.00001288295,0.00001465947,0.00004500911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.2902359,0.01812328,0.003588195,0.002016846,0.001476597,0.0003030099,0.0001625694,0.001825544,0.528588,0.0003581682,0.003038937,0.150283],"study_design_scores_gemma":[0.1753802,0.5148941,0.03357755,0.0002107559,0.002599208,0.0008574344,0.0002115638,0.005184142,0.2552473,0.0003395385,0.0114082,0.00009006077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942921,0.002434773,0.0004343452,0.0002415773,0.0001618726,0.0002808486,0.0003386481,0.0000874002,0.00172831],"genre_scores_gemma":[0.9947956,0.001381282,0.001088126,0.00024728,0.00005846048,0.0003172114,0.0004264461,0.00001221115,0.001673267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004908801,"threshold_uncertainty_score":0.01642156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102677052122319,"score_gpt":0.2717787119014702,"score_spread":0.2615110066892383,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}