{"id":"W2800649646","doi":"10.1038/s41421-018-0022-5","title":"Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis","year":2018,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stem Cell Network; Esri (Canada); Ottawa Hospital; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Food and Agriculture; National Institutes of Health; Ottawa Hospital Research Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society; U.S. Department of Agriculture","keywords":"PRC2; Wnt signaling pathway; Cell biology; Erythropoiesis; Biology; Epigenetics; Histone H3; Histone; Genetics; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001721015,0.0001242581,0.0001761696,0.00002732012,0.00007363802,0.00002329563,0.000112411,0.0001380735,0.00002423141],"category_scores_gemma":[0.00010019,0.0001174173,0.0001542766,0.00004850769,0.0001841894,0.000006534487,0.00004621395,0.00003378173,0.000005518655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001262826,"about_ca_system_score_gemma":0.0001362009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003169445,"about_ca_topic_score_gemma":0.00002319304,"domain_scores_codex":[0.9991062,0.00004136255,0.0002545507,0.0002890643,0.0001019851,0.0002068833],"domain_scores_gemma":[0.999337,0.00006173149,0.0001355695,0.0002340754,0.0001811835,0.00005050373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002150886,0.00006119935,0.0007373655,0.00002757236,0.00004637219,3.512284e-7,0.00007520437,0.00002985319,0.9978452,0.0002532797,0.000369571,0.0003389198],"study_design_scores_gemma":[0.000917223,0.0006855215,0.0004956565,0.00001503134,0.0000435048,2.661422e-7,0.00008630809,0.00009925981,0.9914505,0.0007736341,0.005281905,0.0001512011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9148313,0.001608096,0.08035798,0.0001011166,0.000196671,0.000244449,0.0001785749,0.000004872124,0.002476912],"genre_scores_gemma":[0.9976078,0.0001940194,0.0009613427,0.0002562707,0.0003560622,0.0000229734,0.00009137098,0.00002391581,0.0004862069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08277652,"threshold_uncertainty_score":0.4788138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633169656510412,"score_gpt":0.2682051729859553,"score_spread":0.2518734764208511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}