{"id":"W2800649646","doi":"10.1038/s41421-018-0022-5","title":"Mtf2-PRC2 control of canonical Wnt signaling is required for definitive erythropoiesis","year":2018,"lang":"en","type":"article","venue":"Cell Discovery","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stem Cell Network; Esri (Canada); Ottawa Hospital; University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Food and Agriculture; National Institutes of Health; Ottawa Hospital Research Institute; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society; U.S. Department of Agriculture","keywords":"PRC2; Wnt signaling pathway; Cell biology; Erythropoiesis; Biology; Epigenetics; Histone H3; Histone; Genetics; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009638158,0.0003297907,0.0001540177,0.0001876705,0.0002196803,0.0003240943,0.0001986805,0.0002245086,0.001490982],"category_scores_gemma":[0.0001063773,0.0001633628,0.0001488016,0.0001191535,0.0003000448,0.0001699623,0.0002426205,0.0003665033,0.0004217289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004956408,"about_ca_system_score_gemma":0.0002662991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001174556,"about_ca_topic_score_gemma":0.002758647,"domain_scores_codex":[0.9998481,0.00001480082,0.0000116012,0.00004715692,0.00005341908,0.00002494426],"domain_scores_gemma":[0.9998908,0.00000958419,0.00003668082,0.00001463592,0.00001170545,0.00003655657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001773036,0.000002357028,0.0001166678,0.000008264377,0.000001058135,0.00002602378,0.000003176108,0.00001680239,0.9993727,0.0001260822,0.00001826147,0.000290919],"study_design_scores_gemma":[0.000003659539,0.00001906134,0.00450033,0.000001764299,0.000002682212,0.0002168648,0.000007689925,0.0005142849,0.9921384,0.0000406908,0.00255272,0.000001736675],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767001,0.002203517,0.01416472,0.0002060957,0.00004977518,0.00003850508,0.001374305,0.0003148661,0.004947973],"genre_scores_gemma":[0.9904074,0.000345815,0.002496396,0.00003263961,0.000008707388,0.00002266309,0.0006739754,0.00003872795,0.005973684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001490982,"threshold_uncertainty_score":0.004987836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01633169656510412,"score_gpt":0.2682051729859553,"score_spread":0.2518734764208511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}