{"id":"W2800659064","doi":"10.1016/j.dadm.2018.03.003","title":"Development and validation of a salivary tau biomarker in Alzheimer's disease","year":2018,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Baycrest Hospital; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Saliva; Biomarker; Cerebrospinal fluid; Phosphorylation; Western blot; Alzheimer's disease; Internal medicine; Tau protein; Hippocampal formation; Medicine; Endocrinology; Pathology; Disease; Oncology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004447065,0.0005218184,0.0005602948,0.000526681,0.0002738945,0.0001056388,0.0002143392,0.00008790653,0.0002560921],"category_scores_gemma":[0.00005367398,0.0005034886,0.0001953196,0.0005585849,0.0002799147,0.0005267247,0.0003298985,0.0001813088,0.00004604769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001101258,"about_ca_system_score_gemma":0.0008762119,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001392054,"about_ca_topic_score_gemma":0.000006824047,"domain_scores_codex":[0.9960245,0.000195246,0.0008719214,0.0009091039,0.001197735,0.0008015158],"domain_scores_gemma":[0.9970888,0.0001629199,0.0002666616,0.0006799782,0.0002922445,0.001509426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006195274,0.002520766,0.9427096,0.00007343387,0.02450883,0.0003098176,0.0001569692,0.000003107481,0.0001607756,0.00007478605,0.0002697439,0.02859262],"study_design_scores_gemma":[0.002573254,0.0001675333,0.9621088,0.0006603343,0.01557732,0.000001857016,0.0001483433,0.0001596149,0.01743557,0.0001017576,0.0006421649,0.0004234871],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9025198,0.09486588,0.00002988396,0.0004396792,0.0003164916,0.00145903,0.00006424708,0.00008639804,0.0002185856],"genre_scores_gemma":[0.9922377,0.001350882,0.004426697,0.00006618568,0.0002201519,0.001339276,0.000275512,0.00008201481,0.0000016227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.093515,"threshold_uncertainty_score":0.9997417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06156415338477877,"score_gpt":0.3661124911527091,"score_spread":0.3045483377679303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}