{"id":"W2800659548","doi":"10.1016/j.celrep.2018.04.019","title":"The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Institute for Research in Immunology and Cancer; McGill University Health Centre; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fondation du cancer du sein du Québec; McGill University","keywords":"GAS6; AXL receptor tyrosine kinase; Intravasation; Metastatic breast cancer; Breast cancer; Cancer research; Receptor tyrosine kinase; Metastasis; Cancer; Medicine; Extravasation; Trastuzumab; Oncology; Internal medicine; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792719,0.0001844441,0.0001853204,0.0004841965,0.0003004536,0.000661899,0.00014532,0.0003413105,0.001574115],"category_scores_gemma":[0.0002503318,0.0001873923,0.0001292292,0.000225634,0.0001922372,0.0002973367,0.0003481617,0.0005142873,0.000403386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004570686,"about_ca_system_score_gemma":0.0002774367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001268816,"about_ca_topic_score_gemma":0.00169249,"domain_scores_codex":[0.999792,0.00002606273,0.00001279798,0.00002437719,0.00006425408,0.00008055548],"domain_scores_gemma":[0.9998268,0.00001480304,0.00006335466,0.00001286908,0.0000232051,0.00005883824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001909242,0.0001452929,0.0384933,0.00004535945,0.00003005213,0.0005706262,0.00008413848,0.0002230582,0.9519259,0.0003548137,0.0007753688,0.0054428],"study_design_scores_gemma":[0.00007344685,0.0007765043,0.6326952,0.00002059816,0.00006882993,0.002298197,0.0004930877,0.002700333,0.3545589,0.0004505227,0.005841,0.0000232384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982097,0.0006608159,0.0002254867,0.00009086131,0.000008554452,0.000005450733,0.0001732754,0.00002214488,0.00060361],"genre_scores_gemma":[0.9982096,0.0002080001,0.0001280314,0.0000304667,0.000005749318,0.000007364403,0.0002747091,0.000003968689,0.001132304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001574115,"threshold_uncertainty_score":0.005266011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01113999905167563,"score_gpt":0.2558665293899014,"score_spread":0.2447265303382258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}