{"id":"W2800727579","doi":"10.1371/journal.pgen.1007356","title":"An interplay between multiple sirtuins promotes completion of DNA replication in cells with short telomeres","year":2018,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé; Institute of Genetics; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Sirtuin; Telomere; Cell biology; Histone; DNA damage; DNA repair; Chromatin; DNA replication; G2-M DNA damage checkpoint; Saccharomyces cerevisiae; Histone H4; Telomere-binding protein; Genetics; Cell cycle; DNA; Acetylation; Cell cycle checkpoint; Cell; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001796699,0.0003669037,0.0004012802,0.0002351802,0.0001571931,0.0004408997,0.0002049944,0.0002520468,0.0009166849],"category_scores_gemma":[0.0001569933,0.0001538981,0.0003554688,0.0001551594,0.0001896915,0.0002987993,0.0004207691,0.0003080645,0.0003719389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002761313,"about_ca_system_score_gemma":0.0001503783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002670061,"about_ca_topic_score_gemma":0.0004952324,"domain_scores_codex":[0.9998815,0.0000121937,0.00001457023,0.00003884275,0.00002731014,0.00002560232],"domain_scores_gemma":[0.9998293,0.00001777815,0.00005355733,0.00002073937,0.00002205369,0.00005654721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006707862,0.000005067589,0.0005243476,0.00001702607,0.000004214393,0.0000267963,0.000006130041,0.00002394485,0.9985626,0.00002824375,0.000009230152,0.000725299],"study_design_scores_gemma":[0.00001961331,0.0003223643,0.03724096,0.000007081826,0.00002692803,0.0003871889,0.00004789475,0.001149715,0.9584805,0.0001376521,0.002169557,0.00001052231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919037,0.003968791,0.003105802,0.00007429609,0.00002543853,0.000009064072,0.0002085047,0.0001275327,0.0005768937],"genre_scores_gemma":[0.9970006,0.0007018927,0.00117199,0.0000301773,0.00001361075,0.000007760142,0.0003607105,0.00001760952,0.0006955158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009166849,"threshold_uncertainty_score":0.003066659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03640895684264119,"score_gpt":0.3245847029259972,"score_spread":0.2881757460833561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}