{"id":"W2800727579","doi":"10.1371/journal.pgen.1007356","title":"An interplay between multiple sirtuins promotes completion of DNA replication in cells with short telomeres","year":2018,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Fonds de Recherche du Québec - Santé; Institute of Genetics; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Sirtuin; Telomere; Cell biology; Histone; DNA damage; DNA repair; Chromatin; DNA replication; G2-M DNA damage checkpoint; Saccharomyces cerevisiae; Histone H4; Telomere-binding protein; Genetics; Cell cycle; DNA; Acetylation; Cell cycle checkpoint; Cell; DNA-binding protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842972,0.0001331926,0.0003300528,0.0001507769,0.00003335208,0.000006977646,0.0001164811,0.00009188226,0.0000380795],"category_scores_gemma":[0.0000653789,0.00009586747,0.00002608865,0.0002166964,0.0002277159,0.0000304715,0.00002436709,0.0001349654,0.00000671985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003413011,"about_ca_system_score_gemma":0.00004632149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000228515,"about_ca_topic_score_gemma":0.0001121191,"domain_scores_codex":[0.998805,0.00004359824,0.0003485369,0.0003152833,0.0003057563,0.0001818312],"domain_scores_gemma":[0.9988714,0.00006175489,0.00008193642,0.0006402723,0.0002338468,0.0001107453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001131916,0.0002896145,0.4018178,0.00006524025,0.00004172498,0.000003395957,0.000557159,0.000009304244,0.5939375,0.00000276607,0.00005504881,0.003107313],"study_design_scores_gemma":[0.0008566798,0.003291124,0.1907856,0.0002514659,0.000109636,0.000006917703,0.0001789285,0.009561399,0.7945338,0.00001228368,0.0003119572,0.0001002108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998075,0.00008478873,0.0006769467,0.0001689854,0.0000428985,0.0005792576,0.00001551702,0.00003275248,0.0003238239],"genre_scores_gemma":[0.9944139,0.00003455345,0.00482148,0.0000861415,0.0004716019,0.00001585093,0.00009606621,0.00002806947,0.00003233639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2110322,"threshold_uncertainty_score":0.3909362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03640895684264119,"score_gpt":0.3245847029259972,"score_spread":0.2881757460833561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}