{"id":"W2800767974","doi":"10.1053/j.seminhematol.2018.04.011","title":"Curative therapies: Allogeneic hematopoietic cell transplantation from matched related donors using myeloablative, reduced intensity, and nonmyeloablative conditioning in sickle cell disease","year":2018,"lang":"en","type":"review","venue":"Seminars in Hematology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"Medicine; Busulfan; Alemtuzumab; Transplantation; Total body irradiation; Internal medicine; Regimen; Immunosuppression; Oncology; Hematopoietic stem cell transplantation; Fludarabine; Cyclophosphamide; Immunology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000332289,0.0007886444,0.002997304,0.0007437583,0.0001371786,0.00002594986,0.0001802825,0.001130107,0.0001659157],"category_scores_gemma":[0.0001046395,0.0006912458,0.0002938633,0.0008576839,0.0006695053,0.0001535894,0.00009615654,0.001163824,0.00004107876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003092409,"about_ca_system_score_gemma":0.0005052745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002378281,"about_ca_topic_score_gemma":0.00004871866,"domain_scores_codex":[0.9959927,0.0005801921,0.001497194,0.001079111,0.0002285855,0.0006222097],"domain_scores_gemma":[0.9977216,0.0007034293,0.0007772577,0.0004213879,0.0001261309,0.0002502312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"qualitative","study_design_gemma":"systematic_review","study_design_scores_codex":[0.008572021,0.008176625,0.08265397,0.2828099,0.006514291,0.04399502,0.4739216,0.0005557073,0.003395825,0.002224595,0.00188407,0.0852963],"study_design_scores_gemma":[0.0397909,0.003100643,0.005591257,0.7298744,0.02667857,0.01277881,0.09128574,0.005710963,0.006296225,0.03448432,0.03148963,0.0129186],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2465782,0.7507588,0.00004952748,0.0001019337,0.0002396405,0.001608205,0.00009344074,0.00004935314,0.000520955],"genre_scores_gemma":[0.06251169,0.9351341,0.0009637759,0.00009287025,0.00002749567,0.0001072421,0.0009313105,0.0001125372,0.0001190467],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4470644,"threshold_uncertainty_score":0.9995539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253164265541818,"score_gpt":0.2998009161361334,"score_spread":0.2772692734807152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}