{"id":"W2800767974","doi":"10.1053/j.seminhematol.2018.04.011","title":"Curative therapies: Allogeneic hematopoietic cell transplantation from matched related donors using myeloablative, reduced intensity, and nonmyeloablative conditioning in sickle cell disease","year":2018,"lang":"en","type":"review","venue":"Seminars in Hematology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"Medicine; Busulfan; Alemtuzumab; Transplantation; Total body irradiation; Internal medicine; Regimen; Immunosuppression; Oncology; Hematopoietic stem cell transplantation; Fludarabine; Cyclophosphamide; Immunology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000245896,0.000220937,0.0002006478,0.0002789135,0.0002891826,0.0001917821,0.0002452738,0.0002346926,0.003747948],"category_scores_gemma":[0.0001489543,0.00004125191,0.0001992365,0.0001991558,0.0002215579,0.0002036509,0.0002760387,0.0004925992,0.0008139539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000238187,"about_ca_system_score_gemma":0.0003134276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002437406,"about_ca_topic_score_gemma":0.0005223699,"domain_scores_codex":[0.9999309,0.00001572301,0.000005818319,0.0000138603,0.00002363894,0.00001011484],"domain_scores_gemma":[0.9999676,0.00000497129,0.000009473258,0.000003792577,0.000003268648,0.00001100606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001536478,0.001333,0.006327326,0.002300212,0.0001194879,0.002245818,0.0002611538,0.0009021504,0.05108592,0.007383684,0.02479494,0.9017098],"study_design_scores_gemma":[0.002918152,0.01773675,0.1120408,0.003315985,0.0006673702,0.0747759,0.0002988109,0.003087147,0.08530959,0.01993084,0.6798081,0.000110624],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4669273,0.4071316,0.03915758,0.007729379,0.001652571,0.001187859,0.001228338,0.001169808,0.07381574],"genre_scores_gemma":[0.8881977,0.07780015,0.01086026,0.003339351,0.001324818,0.00047895,0.001696258,0.00005276895,0.01624984],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003747948,"threshold_uncertainty_score":0.01253814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02253164265541818,"score_gpt":0.2998009161361334,"score_spread":0.2772692734807152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}