{"id":"W2800768796","doi":"10.1074/jbc.ra117.001444","title":"HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis","year":2018,"lang":"es","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Centrosome; Cell biology; Centriole; Biology; Ubiquitin ligase; Microtubule organizing center; Ubiquitin; Microtubule; Cell; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0005149117,0.0004693951,0.0009386264,0.0001038387,0.000302899,0.0000913283,0.0008149936,0.0008786371,0.008197774],"category_scores_gemma":[0.0008126606,0.000305999,0.0005247763,0.0002983311,0.0009992064,0.00009089056,0.0003930218,0.001034692,0.00497795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002748314,"about_ca_system_score_gemma":0.000239848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007555684,"about_ca_topic_score_gemma":6.169796e-7,"domain_scores_codex":[0.9969798,0.0002745529,0.0009538181,0.0004893614,0.0001831055,0.001119351],"domain_scores_gemma":[0.9976882,0.0003256163,0.0005147267,0.0004469855,0.0005107847,0.0005137302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002588294,0.00130407,0.03163863,0.00008916596,0.001177235,0.0005120193,0.0002035246,9.19508e-7,0.902135,0.00002941918,0.04562626,0.01469553],"study_design_scores_gemma":[0.002955767,0.003381219,0.02383689,0.0002505592,0.0001393047,0.001052612,0.0003911359,6.126207e-7,0.6023671,0.0001043187,0.3650867,0.0004337637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817786,0.008971605,0.00009290737,0.004311302,0.000577764,0.0002052471,0.0008550573,0.00002792439,0.003179645],"genre_scores_gemma":[0.9927622,0.002279863,0.0002850024,0.0003928421,0.001397576,0.000007868115,0.000147962,0.00002223366,0.00270447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3194605,"threshold_uncertainty_score":0.9999392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02135126813809606,"score_gpt":0.2929029239223572,"score_spread":0.2715516557842611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}