{"id":"W2800768796","doi":"10.1074/jbc.ra117.001444","title":"HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis","year":2018,"lang":"es","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Centrosome; Cell biology; Centriole; Biology; Ubiquitin ligase; Microtubule organizing center; Ubiquitin; Microtubule; Cell; Genetics; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001153673,0.0002916396,0.0002499269,0.0001670169,0.0001554683,0.0004086391,0.0002737371,0.0003005946,0.001339515],"category_scores_gemma":[0.00008760812,0.0001837105,0.0002217339,0.000102144,0.0001614226,0.0002138305,0.0001957773,0.0005535695,0.0004211865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005497977,"about_ca_system_score_gemma":0.0001614971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000487892,"about_ca_topic_score_gemma":0.000660818,"domain_scores_codex":[0.9998499,0.00001574821,0.0000160662,0.00003514358,0.00003913616,0.00004394636],"domain_scores_gemma":[0.9999485,0.000007381257,0.00001670245,0.000008962499,0.000003756035,0.00001461251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007503032,0.00002372083,0.000164014,0.00003530573,0.00001048472,0.00007018477,0.000005278355,0.00008152779,0.9980331,0.0001799669,0.00009505829,0.001226226],"study_design_scores_gemma":[0.0000178325,0.0001000316,0.002493503,0.000004011232,0.00001170911,0.0004576466,0.00001347689,0.001143082,0.9923509,0.00005096238,0.003353279,0.000003594335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914274,0.003486336,0.002349944,0.0001804839,0.00006553934,0.00002917613,0.0004840356,0.0001493574,0.001827625],"genre_scores_gemma":[0.9961672,0.0007280546,0.0009791432,0.00004244447,0.000005667618,0.00001495931,0.0003206207,0.00001478962,0.001727059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339515,"threshold_uncertainty_score":0.004481137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02135126813809606,"score_gpt":0.2929029239223572,"score_spread":0.2715516557842611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}