{"id":"W2800778398","doi":"10.7554/elife.34311","title":"Donated chemical probes for open science","year":2018,"lang":"en","type":"article","venue":"eLife","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Novartis Pharma; Bayer; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Deutsche Forschungsgemeinschaft; Cancer Research UK; Ontario Ministry of Economic Development and Innovation; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Wellcome Trust; Pfizer","keywords":"Chemical biology; Pharmaceutical industry; Function (biology); Drug industry; Control (management); Chemical industry; Pharmaceutical sciences; Open science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["open_science","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.007543828,0.001657519,0.001711003,0.003052929,0.002705374,0.006404992,0.005335968,0.006846228,0.46384],"category_scores_gemma":[0.01418446,0.001949784,0.001483916,0.005446257,0.002873579,0.007679463,0.00938462,0.007419047,0.3023997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003338122,"about_ca_system_score_gemma":0.003936548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005633498,"about_ca_topic_score_gemma":0.001490097,"domain_scores_codex":[0.9938116,0.001425767,0.0003388778,0.001316459,0.002370322,0.0007369419],"domain_scores_gemma":[0.9927189,0.001428382,0.0006537031,0.002580181,0.001046689,0.001572004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005300647,0.0001367998,0.0002288599,0.002048773,0.00007971397,0.0003895762,0.0003787132,0.0005720166,0.02729245,0.161804,0.6375569,0.1689823],"study_design_scores_gemma":[0.00008283379,0.00002850999,0.00006529606,0.00009165369,0.000008363468,0.0001324223,0.00002258481,0.0001783034,0.003757446,0.008753192,0.9868631,0.00001618057],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.003240326,0.01568529,0.2022741,0.01227527,0.02397108,0.001824972,0.03178041,0.04487918,0.6640693],"genre_scores_gemma":[0.04078042,0.02006664,0.1770864,0.009270743,0.004112137,0.01204607,0.05571662,0.02147905,0.6594419],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.994664,"threshold_uncertainty_score":0.7647672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181165383791121,"score_gpt":0.3181606005522178,"score_spread":0.3000440621731057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}