{"id":"W2800885900","doi":"10.3389/fnagi.2018.00155","title":"Associations of MAP2K3 Gene Variants With Superior Memory in SuperAgers","year":2018,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson Pharmaceutical Research and Development; Janssen Pharmaceuticals; National Institute on Aging; Canadian Institutes of Health Research; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; U.S. Department of Defense; Eli Lilly and Company; Lundbeckfonden; Davee Foundation; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; IXICO; Takeda Pharmaceutical Company; AbbVie; Novartis; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; University of Southern California; Roche; Alzheimer's Drug Discovery Foundation; Merck; Fujirebio Europe; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Johnson and Johnson; Meso Scale Diagnostics","keywords":"Exome sequencing; Single-nucleotide polymorphism; Dementia; Biology; Phenotype; Exon; Genetics; Gene; Cognitive decline; Alzheimer's disease; Genetic association; Disease; Frontotemporal dementia; Intron; Medicine; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000280153,0.0004290782,0.000329613,0.0004762118,0.0003840866,0.0004371142,0.0002098829,0.0003378688,0.004241148],"category_scores_gemma":[0.0008290266,0.0001347916,0.0004636982,0.0006133284,0.0002600017,0.0002815405,0.000336642,0.0003236552,0.0002778094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000098212,"about_ca_system_score_gemma":0.000136441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001444455,"about_ca_topic_score_gemma":0.001578043,"domain_scores_codex":[0.9999007,0.00001442052,0.0000145311,0.00003989215,0.00001378038,0.00001665822],"domain_scores_gemma":[0.9996517,0.00005809883,0.0001722619,0.00002919488,0.00003121871,0.00005752396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005609872,0.00004053002,0.9872426,0.00005311875,0.0001466221,0.001451405,0.000274794,0.00007859094,0.005201648,0.0001564994,0.000314897,0.004478282],"study_design_scores_gemma":[0.00001646451,0.0001699674,0.9935226,0.00002303268,0.0001754169,0.003901449,0.0002210571,0.0001982497,0.0009269373,0.0003209513,0.0005169575,0.000006844924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991164,0.0002298071,0.0001229562,0.00003611068,0.000005599391,0.000003682379,0.0002183197,0.000003879099,0.0002633119],"genre_scores_gemma":[0.9993052,0.0001171546,0.0001388684,0.00002771236,0.000009516189,0.00000423695,0.0002205063,0.000003124435,0.0001735973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004241148,"threshold_uncertainty_score":0.01418805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02795377413417177,"score_gpt":0.300299859283184,"score_spread":0.2723460851490122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}