{"id":"W2800885900","doi":"10.3389/fnagi.2018.00155","title":"Associations of MAP2K3 Gene Variants With Superior Memory in SuperAgers","year":2018,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson Pharmaceutical Research and Development; Janssen Pharmaceuticals; National Institute on Aging; Canadian Institutes of Health Research; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; U.S. Department of Defense; Eli Lilly and Company; Lundbeckfonden; Davee Foundation; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; IXICO; Takeda Pharmaceutical Company; AbbVie; Novartis; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; University of Southern California; Roche; Alzheimer's Drug Discovery Foundation; Merck; Fujirebio Europe; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Johnson and Johnson; Meso Scale Diagnostics","keywords":"Exome sequencing; Single-nucleotide polymorphism; Dementia; Biology; Phenotype; Exon; Genetics; Gene; Cognitive decline; Alzheimer's disease; Genetic association; Disease; Frontotemporal dementia; Intron; Medicine; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002145589,0.00009843158,0.000220016,0.0003154922,0.00007458516,0.00001720613,0.0001417522,0.00002859316,0.00001225953],"category_scores_gemma":[0.0001630679,0.00008194664,0.00002808783,0.0008240457,0.0004043645,0.0001805658,0.00003865956,0.0001257293,0.000003161888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001199191,"about_ca_system_score_gemma":0.0003038124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001681662,"about_ca_topic_score_gemma":0.00002852084,"domain_scores_codex":[0.99867,0.00006257057,0.0001754299,0.0003166137,0.0004067337,0.0003686844],"domain_scores_gemma":[0.9994988,0.00002201494,0.00004093749,0.0002292629,0.00006185515,0.0001471163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007131458,0.0002376804,0.9939629,0.000009788227,0.00004168504,0.0002683342,0.0004001166,0.00001468753,0.004255949,0.000005936824,0.0002422494,0.0004893906],"study_design_scores_gemma":[0.001430558,0.0002835586,0.9892784,0.00007282223,0.00003177019,0.0000154345,0.0001492732,0.001723032,0.006880566,0.00003430253,0.00001979176,0.00008046001],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975805,0.0003000959,0.0004662109,0.0002568213,0.0002915695,0.000293221,0.00002797786,0.00001832266,0.0007653271],"genre_scores_gemma":[0.996317,0.00004245804,0.003296921,0.0002160233,0.00002623437,0.00001302424,0.000005808462,0.00001150205,0.00007104137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004684437,"threshold_uncertainty_score":0.3341687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02795377413417177,"score_gpt":0.300299859283184,"score_spread":0.2723460851490122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}