{"id":"W2800918169","doi":"10.3389/fphys.2018.00611","title":"Effect of Mutated Cu, Zn Superoxide Dismutase (SOD1G93A) on Modulation of Transductional Pathway Mediated by M1 Muscarinic Receptor in SK-N-BE and NSC-34 Cells","year":2018,"lang":"en","type":"article","venue":"Frontiers in Physiology","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; National Science Council","keywords":"Superoxide dismutase; BAPTA; SOD1; Chemistry; Protein kinase B; Muscarinic acetylcholine receptor; Cell biology; Muscarinic acetylcholine receptor M1; Receptor; Reactive oxygen species; Biochemistry; Molecular biology; Signal transduction; Biology; Antioxidant","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002124024,0.000455227,0.0005595679,0.0002028146,0.0001986369,0.000340463,0.0002717188,0.0004068371,0.000916346],"category_scores_gemma":[0.0001646379,0.0001407883,0.0004161571,0.000215233,0.0001972149,0.000202767,0.0001866432,0.0007178276,0.000338144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002312499,"about_ca_system_score_gemma":0.0002453901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001668968,"about_ca_topic_score_gemma":0.002149536,"domain_scores_codex":[0.9997839,0.00004134907,0.000043138,0.00003318621,0.00004872622,0.00004969432],"domain_scores_gemma":[0.9998916,0.00001904221,0.00002569364,0.00001566848,0.00001611382,0.00003185937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007573484,0.0003073096,0.0002569729,0.0001030875,0.00002713565,0.0002231501,0.00008828229,0.0001207365,0.9964249,0.0001169455,0.0001772042,0.001397051],"study_design_scores_gemma":[0.0002049245,0.003468939,0.009626964,0.00002777819,0.0001151891,0.0005136457,0.000182024,0.002071438,0.9792118,0.0001250751,0.004432343,0.00001980985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967739,0.001387741,0.000345966,0.0001574397,0.00006386674,0.00003083788,0.0004497186,0.00005052719,0.0007399863],"genre_scores_gemma":[0.9955047,0.001135416,0.0006877351,0.00008858541,0.00001168705,0.00006845049,0.0007941169,0.000009489278,0.001699836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001668968,"threshold_uncertainty_score":0.003318548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009385265887127766,"score_gpt":0.262124337208828,"score_spread":0.2527390713217002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}