{"id":"W2800987625","doi":"10.1016/j.bbagen.2018.03.001","title":"Stress-induced acidification may contribute to formation of unusual structures in C9orf72-repeats","year":2018,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; McMaster University; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Weston Brain Institute","keywords":"C9orf72; Trinucleotide repeat expansion; DNA; Chemistry; Biophysics; Neurodegeneration; Circular dichroism; Biochemistry; Structural motif; Crystallography; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002057193,0.0005980817,0.0003580579,0.0003042218,0.0005293475,0.0003610536,0.0004743123,0.001097143,0.003616125],"category_scores_gemma":[0.0004802272,0.000178836,0.0007399967,0.0002125073,0.0003761055,0.00048398,0.0004771625,0.0006928784,0.000791464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002819881,"about_ca_system_score_gemma":0.0001969015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006215969,"about_ca_topic_score_gemma":0.0007812596,"domain_scores_codex":[0.9998246,0.00002280028,0.00002427785,0.00006035336,0.00002717212,0.00004076067],"domain_scores_gemma":[0.9996423,0.0000450708,0.000171166,0.00003778888,0.00003305681,0.00007074314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006958703,0.00005599989,0.007796604,0.0001204929,0.00007886827,0.007198409,0.0001193058,0.0006466589,0.9788049,0.0007729651,0.000465069,0.003244764],"study_design_scores_gemma":[0.0001453804,0.0008175622,0.1409966,0.00005657083,0.0002166039,0.01875478,0.000440181,0.007894472,0.818876,0.002860818,0.008781474,0.0001595213],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958728,0.0004942211,0.002343586,0.0001730433,0.0000876393,0.00002507873,0.0002383372,0.00009794629,0.0006672535],"genre_scores_gemma":[0.9981193,0.00007427953,0.0007848015,0.00006341327,0.00003019883,0.00001452041,0.0002787918,0.00001752598,0.0006170767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003616125,"threshold_uncertainty_score":0.01209712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01329398665048128,"score_gpt":0.2731272034210946,"score_spread":0.2598332167706133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}