{"id":"W2801024124","doi":"10.3389/fnins.2018.00344","title":"Import and Export of Misfolded α-Synuclein","year":2018,"lang":"en","type":"review","venue":"Frontiers in Neuroscience","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Discovery Centre","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Fibril; Endocytosis; Cell biology; Autophagy; Alpha-synuclein; Protein aggregation; Chemistry; Intracellular; Biology; Lewy body; Protein folding; Biophysics; Cell; Parkinson's disease; Biochemistry; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002082563,0.0002849487,0.001269404,0.0003530251,0.00004161669,0.00001378964,0.0002054386,0.0001343824,0.00001542173],"category_scores_gemma":[0.0001034974,0.0002215117,0.0001914422,0.0004893501,0.0003108479,0.00007039251,0.0001003605,0.0001482701,0.000003251268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000658741,"about_ca_system_score_gemma":0.0003279764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003835918,"about_ca_topic_score_gemma":5.536411e-7,"domain_scores_codex":[0.9981913,0.00004884337,0.0004618464,0.0006832331,0.0003237391,0.0002910236],"domain_scores_gemma":[0.9990314,0.00001345197,0.0002801179,0.0004377576,0.00002550736,0.0002117742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006166755,0.0006967668,0.01306623,0.01478594,0.00007400346,0.001575989,0.00006929313,2.295411e-8,0.00006557551,0.00006440438,0.01436619,0.9551739],"study_design_scores_gemma":[0.0003839734,0.000245938,0.002400009,0.003188472,0.0003507182,0.0001285717,0.000006564312,0.00002555836,0.00002767444,0.00005201263,0.993028,0.0001625386],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001364858,0.9959992,0.00009324839,0.000007122528,0.00117138,0.000688464,0.00005088693,0.00002079925,0.000604031],"genre_scores_gemma":[0.0005748548,0.9963497,0.002052116,0.0000788109,0.00004073587,0.00004427871,0.00001061925,0.00003088108,0.00081801],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9786618,"threshold_uncertainty_score":0.9032987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04682849302879614,"score_gpt":0.3225254191091469,"score_spread":0.2756969260803508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}