{"id":"W2801121431","doi":"10.1038/s41434-018-0018-7","title":"Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice","year":2018,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Dental and Craniofacial Research","keywords":"Hyperalgesia; Nerve growth factor; Allodynia; Neuropathic pain; Pharmacology; Biology; Calcium in biology; Tropomyosin receptor kinase A; Neurite; Endocrinology; Nociception; Internal medicine; Cell biology; Receptor; Medicine; Intracellular; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004653574,0.0004165099,0.0006053534,0.0002748698,0.0002336746,0.00005075934,0.0001345715,0.0001762794,0.00007304731],"category_scores_gemma":[0.00001675907,0.0003325059,0.00009778793,0.0004054478,0.0001045613,0.0001257403,0.00003122407,0.0002369518,0.00001079764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001038032,"about_ca_system_score_gemma":0.000107509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000528404,"about_ca_topic_score_gemma":0.00005822746,"domain_scores_codex":[0.9977123,0.0001921015,0.0004077663,0.0007798009,0.0003179228,0.0005901735],"domain_scores_gemma":[0.9990631,0.00002804368,0.0001538169,0.0004200976,0.000148998,0.000185951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002912564,0.0003240418,0.0701361,0.00002070711,0.0002196052,0.0001130749,0.002068349,0.000001925695,0.9230913,0.0000185496,0.0000125822,0.003702528],"study_design_scores_gemma":[0.005479939,0.001235464,0.2221541,0.00008228391,0.00003029068,0.0000565853,0.00004416472,0.00006492739,0.7703063,0.0002383436,0.0000269159,0.0002806828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921052,0.005914643,0.00003453492,0.0004477675,0.00009981256,0.001232993,0.00001025246,0.0001085952,0.00004617366],"genre_scores_gemma":[0.9957892,0.001157291,0.001523253,0.0007280977,0.0005109222,0.00007094476,0.00004347475,0.00008778368,0.00008906178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1527849,"threshold_uncertainty_score":0.9999127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0295551408074054,"score_gpt":0.2787353704860902,"score_spread":0.2491802296786848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}