{"id":"W2801224767","doi":"10.1158/1535-7163.mct-17-1066","title":"Tumor-Independent Host Secretomes Induced By Angiogenesis and Immune-Checkpoint Inhibitors","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"National Cancer Institute; National Institutes of Health; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; Roswell Park Cancer Institute; U.S. Department of Defense","keywords":"Tumor microenvironment; Biomarker; Immune system; Angiogenesis; Transcriptome; Biology; Antibody; Cancer research; Cancer; Immune checkpoint; Immunology; Immunotherapy; Medicine; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307263,0.0001935595,0.0002278536,0.000243008,0.00008176137,0.0002769645,0.00005655685,0.0001372489,0.0008498309],"category_scores_gemma":[0.000110642,0.0000848328,0.0002462528,0.0001225015,0.0001554561,0.0001706037,0.0001489607,0.0003762455,0.0001565187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001662985,"about_ca_system_score_gemma":0.00009162784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001228594,"about_ca_topic_score_gemma":0.0001619233,"domain_scores_codex":[0.9998945,0.00001464847,0.000007472863,0.00002231291,0.00003647045,0.00002456268],"domain_scores_gemma":[0.99986,0.00002377266,0.00005493555,0.00001563679,0.00001888242,0.00002677217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001299578,0.000009291995,0.0004619453,0.0000130675,0.000003846364,0.00001428906,0.000006404769,0.00003160018,0.9988856,0.00002081408,0.00001138297,0.0004119143],"study_design_scores_gemma":[0.00001619221,0.0005640966,0.05658663,0.00000457056,0.00002752557,0.0001990387,0.00004880055,0.001496019,0.9396253,0.00008741629,0.001339333,0.000004995332],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968572,0.0004643745,0.00127569,0.00003006198,0.00001360243,0.00002244983,0.0007152778,0.0000347567,0.0005866527],"genre_scores_gemma":[0.9965507,0.0002666607,0.001062302,0.00004497244,0.00001073693,0.0000345651,0.0007661632,0.00001619148,0.001247817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008498309,"threshold_uncertainty_score":0.002843022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134017122107818,"score_gpt":0.2542033933345853,"score_spread":0.2428632221135071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}