{"id":"W2801224767","doi":"10.1158/1535-7163.mct-17-1066","title":"Tumor-Independent Host Secretomes Induced By Angiogenesis and Immune-Checkpoint Inhibitors","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital; Sunnybrook Health Science Centre","funders":"National Cancer Institute; National Institutes of Health; Roswell Park Alliance Foundation, Roswell Park Cancer Institute; Roswell Park Cancer Institute; U.S. Department of Defense","keywords":"Tumor microenvironment; Biomarker; Immune system; Angiogenesis; Transcriptome; Biology; Antibody; Cancer research; Cancer; Immune checkpoint; Immunology; Immunotherapy; Medicine; Gene; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001460734,0.0003004895,0.0002254334,0.00005880338,0.0001411703,0.00007806251,0.0002299667,0.0001866388,0.00003904951],"category_scores_gemma":[0.00001858604,0.0003096765,0.0001456126,0.0001417144,0.0001797746,0.000004805763,0.0002141807,0.0001087039,0.00001149421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006299595,"about_ca_system_score_gemma":0.0001642312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002314563,"about_ca_topic_score_gemma":0.0001279933,"domain_scores_codex":[0.9985007,0.00005074525,0.0003116072,0.0005245744,0.0002128842,0.0003994717],"domain_scores_gemma":[0.9990643,0.00001193515,0.0001414185,0.0004791078,0.0001590497,0.0001441869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000811845,0.00004397925,0.001470654,0.00001254594,0.000218931,0.000006413017,0.00009230575,0.000002948577,0.9923995,0.00006091926,0.000298228,0.005312431],"study_design_scores_gemma":[0.0006961229,0.0004235685,0.002151183,0.0000193438,0.00009538568,0.00001323571,0.00007845081,0.00004742435,0.9355118,0.00009284979,0.06046833,0.0004022954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769721,0.02050957,0.0007498462,0.0005455899,0.0004426918,0.0002605682,0.000114193,0.0000216036,0.0003838426],"genre_scores_gemma":[0.9943819,0.001916906,0.0002158319,0.002782627,0.0003949108,0.0000604498,0.00005988164,0.00007905429,0.0001084551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0601701,"threshold_uncertainty_score":0.9999355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134017122107818,"score_gpt":0.2542033933345853,"score_spread":0.2428632221135071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}