{"id":"W2801254160","doi":"10.1016/j.jaci.2018.02.055","title":"Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects","year":2018,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":441,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Cilag; Medical Research Council; National Institute of Allergy and Infectious Diseases; Grifols; Medac; Universität Zürich; Bundesministerium für Bildung und Forschung; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Oxford; Therakos; Crohn's and Colitis Foundation; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Japan Blood Products Organization; Immune Deficiency Foundation; Deutsches Zentrum für Infektionsforschung; Bristol-Myers Squibb; CSL Behring; Pfizer; Biogen; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Ministerstvo Zdravotnictví Ceské Republiky; University of Florida Foundation; Instituto de Salud Carlos III; Amgen; National Science Foundation","keywords":"Cytotoxic T cell; Penetrance; Phenotype; Immunology; Antigen; Lymphocyte; Lymphocyte subsets; Lymphocyte activation; Medicine; Biology; Genetics; Immune system; CD8; T cell; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004882852,0.0002370421,0.000815283,0.0001758438,0.000216976,0.00001130957,0.0002522994,0.0004265082,0.0002349019],"category_scores_gemma":[0.00016692,0.0001789868,0.0002373353,0.0001541328,0.002029344,0.0001045955,0.00008051882,0.0002790209,0.00003811216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002959523,"about_ca_system_score_gemma":0.0001861142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001011041,"about_ca_topic_score_gemma":0.00003135858,"domain_scores_codex":[0.9977695,0.0003359454,0.001196734,0.0002701088,0.00005314215,0.0003746224],"domain_scores_gemma":[0.998315,0.0003483549,0.0007293606,0.0002682826,0.0003174552,0.000021499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01104903,0.006094457,0.007947492,0.00002539359,0.009607643,0.00006393993,0.004136561,0.00001109886,0.4682544,0.004367845,0.0002532008,0.4881889],"study_design_scores_gemma":[0.02713043,0.03870687,0.5776425,0.0002314275,0.0004032232,0.001200086,0.002347003,0.0000291871,0.07177103,0.001169741,0.2786079,0.0007605901],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8822551,0.1153283,0.00008736229,0.0001809478,0.001468115,0.0001018783,0.000005181797,0.0000110652,0.0005620454],"genre_scores_gemma":[0.948892,0.05043908,0.00007728812,0.0001258567,0.0000343425,0.000001709477,0.000005326091,0.00001384494,0.0004105477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.569695,"threshold_uncertainty_score":0.7477204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850627878810336,"score_gpt":0.2846964891456913,"score_spread":0.2661902103575879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}