{"id":"W2801254160","doi":"10.1016/j.jaci.2018.02.055","title":"Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects","year":2018,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":441,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Cilag; Medical Research Council; National Institute of Allergy and Infectious Diseases; Grifols; Medac; Universität Zürich; Bundesministerium für Bildung und Forschung; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Oxford; Therakos; Crohn's and Colitis Foundation; Biotechnology and Biological Sciences Research Council; Wellcome Trust; Japan Blood Products Organization; Immune Deficiency Foundation; Deutsches Zentrum für Infektionsforschung; Bristol-Myers Squibb; CSL Behring; Pfizer; Biogen; Deutsche Forschungsgemeinschaft; GlaxoSmithKline; Ministerstvo Zdravotnictví Ceské Republiky; University of Florida Foundation; Instituto de Salud Carlos III; Amgen; National Science Foundation","keywords":"Cytotoxic T cell; Penetrance; Phenotype; Immunology; Antigen; Lymphocyte; Lymphocyte subsets; Lymphocyte activation; Medicine; Biology; Genetics; Immune system; CD8; T cell; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003637652,0.0005404946,0.0003850637,0.0008866586,0.0005831001,0.0004261248,0.0003445729,0.0005923479,0.002349701],"category_scores_gemma":[0.001349892,0.0002556776,0.0003147958,0.0004706584,0.0003845565,0.0003289184,0.000246503,0.0003777524,0.0003708139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003215901,"about_ca_system_score_gemma":0.0002380886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001880978,"about_ca_topic_score_gemma":0.0008613708,"domain_scores_codex":[0.9996526,0.00006998974,0.00004451687,0.00008665497,0.00004867885,0.00009759508],"domain_scores_gemma":[0.9995661,0.0001592915,0.00009727249,0.00003706356,0.00003319791,0.0001070165],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006727704,0.001262948,0.8603163,0.00007884156,0.0001006205,0.04376775,0.001734155,0.0004657783,0.05714494,0.0008525924,0.0006404015,0.02690801],"study_design_scores_gemma":[0.0001370482,0.002358032,0.9441035,0.00003361607,0.0001239245,0.04491245,0.0007242182,0.0005628219,0.004496714,0.0004384315,0.002067539,0.00004166149],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998787,0.0001824227,0.0001129048,0.00002543892,0.000003276842,0.000008560157,0.00009354901,0.000006820087,0.000779989],"genre_scores_gemma":[0.9993336,0.00007384971,0.00006602104,0.00002780034,0.000006230687,0.000005331905,0.0001230562,0.000009245086,0.0003548862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002349701,"threshold_uncertainty_score":0.007860541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01850627878810336,"score_gpt":0.2846964891456913,"score_spread":0.2661902103575879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}