{"id":"W2801261091","doi":"10.1002/glia.23337","title":"<scp>P</scp>arkin deficiency modulates <scp>NLRP</scp>3 inflammasome activation by attenuating an <scp>A</scp>20‐dependent negative feedback loop","year":2018,"lang":"en","type":"article","venue":"Glia","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre For Cold Ocean Resources Engineering","funders":"Seventh Framework Programme; Agence Nationale de la Recherche; European Commission; Institut National de la Santé et de la Recherche Médicale; European Federation of Pharmaceutical Industries and Associations; Fondation de France; Michael J. Fox Foundation for Parkinson's Research","keywords":"Inflammasome; Parkin; PINK1; Neuroinflammation; Biology; Cell biology; Ubiquitin ligase; Microglia; Mitophagy; Signal transduction; Innate immune system; Pathogenesis; Immunology; Inflammation; Ubiquitin; Parkinson's disease; Immune system; Genetics; Autophagy; Medicine; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001432866,0.0004275996,0.0003319986,0.0002794421,0.0001581423,0.000318052,0.0001504028,0.0002998027,0.001335884],"category_scores_gemma":[0.0001158023,0.0001337489,0.000237269,0.000161294,0.000412903,0.0001958995,0.0001929214,0.0006149547,0.0003538804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001911437,"about_ca_system_score_gemma":0.0001416824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004111132,"about_ca_topic_score_gemma":0.0004780621,"domain_scores_codex":[0.9998055,0.00003944429,0.00003919673,0.00004275239,0.00003656353,0.00003656171],"domain_scores_gemma":[0.9997941,0.00002779363,0.00007165082,0.00002032528,0.00001652088,0.00006969136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002775865,0.00003235064,0.00007692548,0.0000173734,0.000003570116,0.00004326485,0.000005611393,0.00001662515,0.9993194,0.00001617704,0.00001501313,0.0001760504],"study_design_scores_gemma":[0.00006531083,0.0008090645,0.006743934,0.000007647011,0.00002486046,0.0004671071,0.0000376205,0.0005112377,0.9901724,0.00004848696,0.001106006,0.000006340309],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978856,0.000429818,0.0007634817,0.0000571826,0.00001499298,0.00002090766,0.0004173986,0.00006212141,0.00034837],"genre_scores_gemma":[0.9972935,0.0002706468,0.0008963275,0.00004082607,0.00001143376,0.00006336988,0.0003501335,0.00002574701,0.001047946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335884,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008872169331322441,"score_gpt":0.2347079714327616,"score_spread":0.2258358021014392,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}