{"id":"W2801312275","doi":"10.1016/j.cell.2018.03.029","title":"The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":271,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vector Institute; Toronto General Hospital; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Occupational Cancer Research Centre; Ontario Institute for Cancer Research","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society; Prostate Cancer Canada; Canada First Research Excellence Fund; Government of Ontario; Compute Canada; Canadian Institutes of Health Research; Genome Canada; Government of Canada; Ontario Institute for Cancer Research; Terry Fox Research Institute; Movember Foundation","keywords":"Biology; Prostate cancer; Prostate; Cancer research; Point mutation; Cancer; Oncology; Gene; Mutation; Internal medicine; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002276306,0.00006861912,0.0001507121,0.00002816031,0.0001319043,0.000005755627,0.00007723959,0.00005285941,0.0001473229],"category_scores_gemma":[0.00004782028,0.00003486633,0.00007251079,0.0001182271,0.0005525448,0.00002380275,0.00004751667,0.0001184468,0.00006593457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005281903,"about_ca_system_score_gemma":0.0003799278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002862766,"about_ca_topic_score_gemma":0.000007780071,"domain_scores_codex":[0.9991738,0.00006239381,0.0002105252,0.0001503239,0.0002067318,0.0001962349],"domain_scores_gemma":[0.9993159,0.0001212551,0.00007921782,0.0002215977,0.0001623375,0.00009966198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01157539,0.0006174134,0.6605214,0.000309485,0.0002656913,0.00009590702,0.001642574,0.000004497589,0.01575529,0.00006057591,0.220779,0.08837284],"study_design_scores_gemma":[0.02361452,0.00733056,0.1769831,0.001633643,0.0002713787,0.00002640377,0.001925539,0.004724966,0.1703501,0.0007773261,0.6119772,0.0003852414],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967914,0.01433507,0.00001913137,0.001045464,0.0004635594,0.0005011819,0.00001260071,0.00002932849,0.0156796],"genre_scores_gemma":[0.9795698,0.008825052,0.0001939121,0.00007216483,0.0002949891,0.00001981971,0.00002213805,0.00001109367,0.01099106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4835382,"threshold_uncertainty_score":0.2035875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02852450337750852,"score_gpt":0.3633687391240666,"score_spread":0.3348442357465581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}