{"id":"W2801346997","doi":"10.1016/j.molmed.2018.04.001","title":"Neuronal Regulation of eIF2α Function in Health and Neurological Disorders","year":2018,"lang":"en","type":"review","venue":"Trends in Molecular Medicine","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"eIF2; Phosphorylation; Translation (biology); Biology; Translational regulation; Eukaryotic initiation factor; Cell biology; Eukaryotic translation; Neurodegeneration; Integrated stress response; Initiation factor; Biochemistry; Medicine; Disease; Internal medicine; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002904747,0.0002395453,0.0006550351,0.0003920366,0.00001682434,0.000003084288,0.000105596,0.0002308336,0.00005805642],"category_scores_gemma":[0.0001318637,0.0001934945,0.0001106112,0.0003897079,0.0002179476,0.000002460932,0.00006186887,0.0001432024,9.389663e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001318904,"about_ca_system_score_gemma":0.00008698671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002014184,"about_ca_topic_score_gemma":0.00004280821,"domain_scores_codex":[0.9981934,0.0003465849,0.0006286752,0.0004631984,0.0001803294,0.0001878513],"domain_scores_gemma":[0.9992557,0.00001697734,0.0002836551,0.0002983462,0.0000207467,0.0001245793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001248784,0.00009023266,0.0006014446,0.001581369,0.00002381938,0.000004471866,0.00001905802,0.00001972786,0.0002041211,0.0002433401,0.0006854038,0.9964021],"study_design_scores_gemma":[0.001662555,0.0021055,0.02407761,0.001817461,0.00009974668,0.00001621472,0.00001011668,0.0001725111,0.000004531008,0.0002844226,0.9694599,0.0002894322],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003806229,0.9947577,0.0003506023,0.0003501604,0.0001266126,0.0002185034,0.000006636782,0.000006661331,0.0003768751],"genre_scores_gemma":[0.01057095,0.9876457,0.00008577787,0.0004009086,0.0001250642,0.00002541064,0.0009199178,0.00003085455,0.000195443],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9961127,"threshold_uncertainty_score":0.7890478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0248231638782192,"score_gpt":0.331287096552549,"score_spread":0.3064639326743298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}