{"id":"W2801498551","doi":"10.1016/j.dadm.2018.03.004","title":"Challenges associated with biomarker‐based classification systems for Alzheimer's disease","year":2018,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Social Fund; National Institute on Aging; Instituto de Salud Carlos III; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Generalitat de Catalunya; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Public Health Service; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; F. Hoffmann-La Roche; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Alzheimer's Drug Discovery Foundation; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Biomarker; Disease; Medicine; Alzheimer's disease; Internal medicine; Oncology; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1324524,0.001215901,0.001911275,0.004025566,0.00194183,0.007175377,0.003214085,0.002334586,0.0007398895],"category_scores_gemma":[0.2525618,0.0005918118,0.001248522,0.002274414,0.002545442,0.003832917,0.002818863,0.001936719,0.0008081621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00221283,"about_ca_system_score_gemma":0.003065726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003776486,"about_ca_topic_score_gemma":0.002829933,"domain_scores_codex":[0.905628,0.06144153,0.01124094,0.007386209,0.01340598,0.0008974151],"domain_scores_gemma":[0.7156965,0.2064453,0.01941223,0.01998884,0.03684381,0.001613377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002544833,0.0006701933,0.5062251,0.001869792,0.002355588,0.0003282004,0.003211894,0.02647431,0.005677884,0.008390853,0.01051029,0.4317411],"study_design_scores_gemma":[0.0005533842,0.002872329,0.3986293,0.003497153,0.001128776,0.002586669,0.005005605,0.4405353,0.01613908,0.1076764,0.02076497,0.0006109679],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.677677,0.0129567,0.2783621,0.01275409,0.001373021,0.002504879,0.0024329,0.001804026,0.01013531],"genre_scores_gemma":[0.875912,0.0007983337,0.1190262,0.001396762,0.0004427648,0.0006596503,0.001263914,0.0001120167,0.0003883828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1324524,"threshold_uncertainty_score":0.7004834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1306193865718007,"score_gpt":0.3912767702229022,"score_spread":0.2606573836511016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}