{"id":"W2801498689","doi":"10.1097/j.pain.0000000000001247","title":"Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain","year":2018,"lang":"en","type":"article","venue":"Pain","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Drug Abuse; U.S. Department of Veterans Affairs","keywords":"Hyperalgesia; DAMGO; Nociception; Naltrexone; Sensitization; Pharmacology; Opioid; Allodynia; Agonist; μ-opioid receptor; Chemistry; Endocrinology; Enkephalin; Receptor; Internal medicine; Opioid receptor; Medicine; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001819969,0.0004030164,0.000409843,0.0002387872,0.0001519,0.0002986632,0.000260787,0.0004015951,0.001549636],"category_scores_gemma":[0.0001865787,0.0002757885,0.0004106624,0.0001608725,0.0003293727,0.0003471003,0.0002475631,0.001295817,0.0003223489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002775691,"about_ca_system_score_gemma":0.0001872053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006055754,"about_ca_topic_score_gemma":0.001580223,"domain_scores_codex":[0.9997175,0.00002909954,0.00002755814,0.00005082746,0.00007556057,0.00009947823],"domain_scores_gemma":[0.9998046,0.00001978738,0.00007310736,0.00002764936,0.00001576465,0.00005923119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007216755,0.00002993883,0.00009482665,0.00002023467,0.000002513829,0.00002370802,0.000006063724,0.000009164537,0.9992975,0.00001389545,0.000008835919,0.0004211661],"study_design_scores_gemma":[0.00009806195,0.003995816,0.04372451,0.00004209499,0.0000599698,0.0009818533,0.00007570396,0.0007286675,0.9489965,0.00006602878,0.001215738,0.00001506598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976729,0.0009475472,0.0007162475,0.00006140518,0.00002110135,0.00001764039,0.0001360682,0.00003151766,0.0003956289],"genre_scores_gemma":[0.9941097,0.001078246,0.001388116,0.00009569435,0.00002590497,0.00008214198,0.0003514707,0.00001657295,0.002852102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549636,"threshold_uncertainty_score":0.005184054,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0122624803456539,"score_gpt":0.2768956517573269,"score_spread":0.264633171411673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}