{"id":"W2801510798","doi":"10.1158/1078-0432.ccr-17-2386","title":"Baseline Tumor Size Is an Independent Prognostic Factor for Overall Survival in Patients with Melanoma Treated with Pembrolizumab","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":309,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Merck","keywords":"Medicine; Pembrolizumab; Internal medicine; Logistic regression; Univariate analysis; Proportional hazards model; Oncology; Post-hoc analysis; Gastroenterology; Stage (stratigraphy); Multivariate analysis; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00165139,0.0002311014,0.0005555735,0.0001522589,0.0001284041,0.00005091572,0.0002386692,0.0001542844,0.00154743],"category_scores_gemma":[0.0006496999,0.00014605,0.0001002658,0.0004927765,0.0006051312,0.0001273231,0.00005177764,0.0005851606,0.00001402625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003577612,"about_ca_system_score_gemma":0.001073194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001688096,"about_ca_topic_score_gemma":0.003452307,"domain_scores_codex":[0.9964729,0.000393806,0.0005961107,0.0007610591,0.001062646,0.0007134698],"domain_scores_gemma":[0.9966772,0.001146099,0.0001166554,0.0005387053,0.001174153,0.0003472119],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1239672,0.001183736,0.8597389,0.00008148832,0.0001847224,0.0000262728,0.0001558668,2.588614e-7,0.00009614134,0.000003260581,0.0005770082,0.01398519],"study_design_scores_gemma":[0.03276578,0.02429314,0.9382862,0.0003132867,0.00004611075,0.000002622819,0.00005628218,0.0001378611,0.0005639842,0.00001208499,0.003312798,0.0002098741],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960688,0.0001053234,0.00001965093,0.0007629272,0.0001274243,0.002425728,0.0002745113,0.00003634421,0.0001792365],"genre_scores_gemma":[0.9973089,0.00005272027,0.0001987986,0.0006844335,0.0005265549,0.0003489593,0.00005598717,0.00006485641,0.0007587506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09120141,"threshold_uncertainty_score":0.9993653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1289801368216482,"score_gpt":0.4481364110601866,"score_spread":0.3191562742385384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}