{"id":"W2801510830","doi":"10.1371/journal.pone.0197262","title":"Evaluation of a novel non-invasive preimplantation genetic screening approach","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's College Hospital; University of Toronto; Canada Research Chairs; CReATe Fertility Centre","funders":"Ontario Centres of Excellence","keywords":"Biology; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004002235,0.0000769141,0.0001746018,0.00007529043,0.0000394363,0.000006487546,0.00005275007,0.00006130158,0.00003234285],"category_scores_gemma":[0.001322755,0.00007196837,0.00002801117,0.000139939,0.00006210017,0.00004682389,0.0000279754,0.00007054236,0.00001648972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000286532,"about_ca_system_score_gemma":0.0001212134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007581495,"about_ca_topic_score_gemma":0.00001020148,"domain_scores_codex":[0.9986432,0.00003304991,0.0001806837,0.0001635739,0.0008513746,0.0001280879],"domain_scores_gemma":[0.9987858,0.0001113826,0.00009907049,0.0001937235,0.000738418,0.00007159487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008616903,0.009821163,0.105546,0.001198091,0.001971196,0.000008004762,0.003402628,0.0009083367,0.8278104,0.000140524,0.0004835309,0.04784847],"study_design_scores_gemma":[0.004533866,0.001042385,0.3108789,0.001207565,0.002958049,0.00002607863,0.0001613018,0.31539,0.3635733,0.00007558629,0.000001743977,0.0001512955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492017,0.000100147,0.04165278,0.00003789245,0.00001502793,0.0005399578,0.00001899134,0.00003091947,0.008402565],"genre_scores_gemma":[0.8590696,0.00001088227,0.1404956,0.0000549075,0.0002147125,0.00003433507,0.0000747688,0.00001134433,0.00003387087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4642371,"threshold_uncertainty_score":0.2934785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1629531656012866,"score_gpt":0.30844735965435,"score_spread":0.1454941940530634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}