{"id":"W2801529820","doi":"10.1002/bdd.2130","title":"Randomized, controlled study of bleselumab (ASKP1240) pharmacokinetics and safety in patients with moderate‐to‐severe plaque psoriasis","year":2018,"lang":"en","type":"article","venue":"Biopharmaceutics & Drug Disposition","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Astellas Pharma; Kyowa Hakko Kirin","keywords":"Medicine; Pharmacokinetics; Tolerability; Placebo; Psoriasis Area and Severity Index; Area under the curve; Psoriasis; Adverse effect; Body surface area; Gastroenterology; Randomized controlled trial; Internal medicine; Urology; Pharmacology; Anesthesia; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005417378,0.0003425621,0.001066317,0.0002793995,0.0001837838,0.00002121872,0.0001423719,0.0001335288,0.0001114863],"category_scores_gemma":[0.00002761807,0.0002543401,0.00009666571,0.0002657833,0.0002002892,0.0001092304,0.00007125101,0.0001493533,0.00003586637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006690053,"about_ca_system_score_gemma":0.00003776896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008532128,"about_ca_topic_score_gemma":0.00007543986,"domain_scores_codex":[0.9976778,0.0007786948,0.0006621043,0.000421458,0.0001163463,0.0003435868],"domain_scores_gemma":[0.9989533,0.0002596011,0.0002575543,0.0002185033,0.0002483324,0.0000627236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9492958,0.003165164,0.02601195,0.00003884473,0.001711798,0.000006650526,0.004435595,0.0001197198,0.008594361,0.0000785159,0.00009852991,0.006443075],"study_design_scores_gemma":[0.9369438,0.0009381952,0.02808082,0.0000927218,0.001857671,0.000004864107,0.0004741118,0.0002437053,0.03076186,0.00002511254,0.0001752172,0.0004019555],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945087,0.0006112706,0.0000641294,0.00008574141,0.0005105626,0.003838256,0.0001420214,0.00003769523,0.0002015512],"genre_scores_gemma":[0.9989069,0.0002520944,0.00008382204,0.0001064365,0.00005317813,0.0002308491,0.0001643045,0.0000287309,0.0001736847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0221675,"threshold_uncertainty_score":0.9999909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01022298846758495,"score_gpt":0.2596460857822547,"score_spread":0.2494230973146698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}