{"id":"W2801545642","doi":"10.1101/gr.228171.117","title":"The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes","year":2018,"lang":"en","type":"article","venue":"Genome Research","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":230,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"University College London Hospitals NHS Foundation Trust; Royal Society; Wellcome Trust","keywords":"Retrotransposon; Biology; Genetics; Gene; Chromatin; Endogenous retrovirus; DNA methylation; Epigenetics; Genome; Heterochromatin; Transposable element; Promoter; Gene silencing; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004363205,0.00007850365,0.00008873166,0.00001284932,0.001259461,0.0002246538,0.0002992114,0.00003779403,0.0004388534],"category_scores_gemma":[0.000046117,0.00002343924,0.00001815355,0.0006143195,0.0002337483,0.00003286641,0.0001119693,0.0001055964,0.00009847407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001487365,"about_ca_system_score_gemma":0.00003341878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001012882,"about_ca_topic_score_gemma":0.008784164,"domain_scores_codex":[0.9987901,0.0001188412,0.0001076677,0.0002873726,0.0003016588,0.0003942957],"domain_scores_gemma":[0.9991969,0.0002165613,0.00001002073,0.0001026737,0.0002573803,0.0002164124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001164645,0.00002468543,0.007238916,0.000002600902,0.00002076419,0.000002360101,0.0005383177,0.000003891897,0.9534063,0.0007681601,0.001271111,0.03660648],"study_design_scores_gemma":[0.0001783169,0.001263394,0.7086014,0.00001073274,0.000005847968,0.0000200475,0.0004659474,0.00003667223,0.006204562,0.000622707,0.2824457,0.0001447131],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845947,0.000573422,0.00001383196,0.01184797,0.00002785706,0.0003709313,0.00003302804,0.00002300808,0.00251527],"genre_scores_gemma":[0.9950499,0.0002172312,0.0002799221,0.00007027987,0.0005885693,0.00002778933,0.00001666349,0.000001209328,0.003748443],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9472017,"threshold_uncertainty_score":0.9686886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1395342241956189,"score_gpt":0.3312354607646599,"score_spread":0.191701236569041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}