{"id":"W2801545642","doi":"10.1101/gr.228171.117","title":"The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes","year":2018,"lang":"en","type":"article","venue":"Genome Research","topic":"Chromosomal and Genetic Variations","field":"Agricultural and Biological Sciences","cited_by":230,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"University College London Hospitals NHS Foundation Trust; Royal Society; Wellcome Trust","keywords":"Retrotransposon; Biology; Genetics; Gene; Chromatin; Endogenous retrovirus; DNA methylation; Epigenetics; Genome; Heterochromatin; Transposable element; Promoter; Gene silencing; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001198371,0.0002880995,0.0001587473,0.0002290948,0.0001380257,0.0002595571,0.0001676962,0.0001573581,0.001365891],"category_scores_gemma":[0.0001114243,0.0001572016,0.0001885674,0.00007684185,0.0001657632,0.0001691512,0.0004537955,0.0002443677,0.0005989016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002846794,"about_ca_system_score_gemma":0.0001698967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003602355,"about_ca_topic_score_gemma":0.0008089233,"domain_scores_codex":[0.9998914,0.00001349319,0.000008085122,0.00003261158,0.00003202104,0.00002235459],"domain_scores_gemma":[0.9998482,0.00001711948,0.00004459243,0.0000194135,0.00001377303,0.00005677891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000361628,0.000005145634,0.0008254722,0.00001471874,0.000005230645,0.00003895683,0.00001069908,0.00005679558,0.9976554,0.0001009927,0.00002423036,0.001226141],"study_design_scores_gemma":[0.000009796997,0.0001259798,0.02109087,0.000003595949,0.00001219386,0.0003456186,0.00003033905,0.002060875,0.9739972,0.00009965793,0.002220126,0.00000380479],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949514,0.0008508195,0.002786048,0.00003187141,0.000008159147,0.000007504797,0.0001284142,0.0001025798,0.001133311],"genre_scores_gemma":[0.9948264,0.0001923143,0.001260822,0.0000214935,0.000004099498,0.000005439132,0.0002914096,0.00002223673,0.003375746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365891,"threshold_uncertainty_score":0.004569411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1395342241956189,"score_gpt":0.3312354607646599,"score_spread":0.191701236569041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}