{"id":"W2801597931","doi":"10.3389/fped.2018.00131","title":"The KOUNCIL Consortium: From Genetic Defects to Therapeutic Development for Nephronophthisis","year":2018,"lang":"en","type":"article","venue":"Frontiers in Pediatrics","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Nierstichting; National Institute for Health and Care Research","keywords":"Medicine; Nephronophthisis; Genetic diagnosis; Pediatrics; Intensive care medicine; Genetics; Gene; Phenotype; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002041432,0.0001721437,0.0001416569,0.00005481618,0.0002162618,0.00004380052,0.000330529,0.00012653,0.000007069245],"category_scores_gemma":[0.0002722605,0.0001416443,0.0000730734,0.0001623325,0.00009718425,0.000001896918,0.0000979691,0.00004780602,0.00002223016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005595941,"about_ca_system_score_gemma":0.0005361031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001139824,"about_ca_topic_score_gemma":0.00005501285,"domain_scores_codex":[0.9987189,0.00004901248,0.0002798671,0.0003824733,0.0001822917,0.000387416],"domain_scores_gemma":[0.9991922,0.0000420111,0.00007110855,0.0003774124,0.0001487903,0.0001684365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007530327,0.000182701,0.2950927,0.00004540483,0.0001962998,0.000005194427,0.0005253719,0.0001616781,0.0144079,0.00001843819,0.6347745,0.05383677],"study_design_scores_gemma":[0.001044797,0.0004052003,0.09151843,0.000006643894,0.0001004779,0.000001203973,0.0003334258,0.000152144,0.01953778,0.001041961,0.8854079,0.0004500147],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8804297,0.01133868,0.1052481,0.0002056902,0.001735923,0.0007709241,0.00005664165,0.00001344743,0.0002008666],"genre_scores_gemma":[0.9034961,0.0007751082,0.09107691,0.001897962,0.001576066,0.0003520646,0.00008318794,0.00004549459,0.0006971376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2506334,"threshold_uncertainty_score":0.5776089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009752672499205025,"score_gpt":0.2325178703233422,"score_spread":0.2227651978241372,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}