{"id":"W2801700172","doi":"10.1007/s12035-018-1045-5","title":"Somatostatin Maintains Permeability and Integrity of Blood-Brain Barrier in β-Amyloid Induced Toxicity","year":2018,"lang":"en","type":"article","venue":"Molecular Neurobiology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Blood–brain barrier; Neurotoxicity; Tight junction; Inflammation; Amyloid beta; Somatostatin; Toxicity; Neuroscience; Biology; Medicine; Endocrinology; Cell biology; Internal medicine; Central nervous system; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002490084,0.0001639288,0.0003584949,0.0001382183,0.00003967172,0.000005282811,0.00008452919,0.0001412993,0.0001125815],"category_scores_gemma":[0.0006312892,0.0001366871,0.00007377897,0.0001811098,0.0005139557,0.00003010809,0.0001251719,0.0002961015,0.00001200481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002614208,"about_ca_system_score_gemma":0.000186062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001646504,"about_ca_topic_score_gemma":0.00008255333,"domain_scores_codex":[0.9984266,0.0004139879,0.0002700472,0.0004124226,0.0001150327,0.0003619519],"domain_scores_gemma":[0.9991276,0.000124116,0.00005616217,0.0003492615,0.0001122181,0.000230631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004941586,0.0007805477,0.2732669,0.0000657016,0.0006969569,0.0004543588,0.0001849252,1.48986e-7,0.7229837,0.0004973148,0.00004193779,0.0005333839],"study_design_scores_gemma":[0.003865836,0.003443898,0.461594,0.00004706555,0.0001939895,0.0001647772,0.00009768597,0.00008171189,0.528926,0.001362661,0.00004893659,0.000173405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979037,0.0001804584,0.00002061668,0.0008694181,0.00003180914,0.0004809517,0.00004529959,0.00002151774,0.0004462175],"genre_scores_gemma":[0.9988808,0.00001134527,0.0002231097,0.0007915644,0.00001847472,0.0000208955,0.00003034409,0.00001607395,0.000007361944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1940577,"threshold_uncertainty_score":0.5573936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02059498821700971,"score_gpt":0.3119888103875541,"score_spread":0.2913938221705444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}