{"id":"W2801801517","doi":"10.1097/fjc.0000000000000594","title":"ApoA-1 Mimetic Peptide ELK-2A2K2E Decreases Inflammatory Factor Levels Through the ABCA1-JAK2-STAT3-TTP Axis in THP-1–Derived Macrophages","year":2018,"lang":"en","type":"article","venue":"Journal of Cardiovascular Pharmacology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Alberta; University of Calgary","funders":"","keywords":"STAT protein; STAT3; ABCA1; Proinflammatory cytokine; Janus kinase; Chemistry; Cytokine; Tumor necrosis factor alpha; Signal transduction; Molecular biology; Inflammation; Interleukin 6; Janus kinase 2; Cell biology; Biology; Endocrinology; Immunology; Biochemistry; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001385047,0.000415335,0.00149252,0.0003236118,0.0001587874,0.0000464042,0.0004737979,0.0002185922,0.0008608904],"category_scores_gemma":[0.0002931598,0.0002764279,0.001625748,0.000392328,0.0006017112,0.000367768,0.0001462577,0.0009603349,0.00008873745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001865834,"about_ca_system_score_gemma":0.0005055781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007383821,"about_ca_topic_score_gemma":0.00001494521,"domain_scores_codex":[0.996197,0.0007674439,0.001093819,0.0003777453,0.0009007253,0.0006632825],"domain_scores_gemma":[0.9977022,0.0003138415,0.0004567402,0.0005772807,0.000620098,0.0003298113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00386788,0.001073094,0.009632894,0.0005560632,0.02487389,0.00644239,0.01114543,0.001009342,0.8533695,0.00006697526,0.02524735,0.06271522],"study_design_scores_gemma":[0.0133351,0.0006853598,0.1729929,0.0001855613,0.003885694,0.004248351,0.0006277711,0.00005455152,0.1841169,0.0001483345,0.6193078,0.0004116915],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649435,0.0290739,0.0007211308,0.001361229,0.002677051,0.0005910869,0.00001614591,0.00003129477,0.0005846709],"genre_scores_gemma":[0.9874598,0.003428282,0.0006245863,0.002433366,0.005711822,0.00002343145,0.000002657779,0.00006538541,0.000250649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6692526,"threshold_uncertainty_score":0.9999688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02792158878583336,"score_gpt":0.3085878951279713,"score_spread":0.280666306342138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}