{"id":"W2801801517","doi":"10.1097/fjc.0000000000000594","title":"ApoA-1 Mimetic Peptide ELK-2A2K2E Decreases Inflammatory Factor Levels Through the ABCA1-JAK2-STAT3-TTP Axis in THP-1–Derived Macrophages","year":2018,"lang":"en","type":"article","venue":"Journal of Cardiovascular Pharmacology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Alberta; University of Calgary","funders":"","keywords":"STAT protein; STAT3; ABCA1; Proinflammatory cytokine; Janus kinase; Chemistry; Cytokine; Tumor necrosis factor alpha; Signal transduction; Molecular biology; Inflammation; Interleukin 6; Janus kinase 2; Cell biology; Biology; Endocrinology; Immunology; Biochemistry; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266887,0.000308784,0.0003289322,0.0001246481,0.0001305287,0.0002300617,0.0001351261,0.0002443136,0.002002129],"category_scores_gemma":[0.00008864545,0.000111409,0.0002206055,0.00009644908,0.0002090202,0.0001887042,0.0001274071,0.0005130578,0.000480332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001345517,"about_ca_system_score_gemma":0.0001537291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001109513,"about_ca_topic_score_gemma":0.0001932259,"domain_scores_codex":[0.999871,0.00002069591,0.00001446593,0.00002413838,0.00003138322,0.00003835286],"domain_scores_gemma":[0.9999425,0.000006799309,0.00002002251,0.000005072753,0.000007520538,0.00001803036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006638622,0.0001061588,0.0001876613,0.00006216724,0.00001136705,0.00004823748,0.000007593675,0.0000651143,0.9979849,0.00002444384,0.00006239537,0.0007759992],"study_design_scores_gemma":[0.0002586208,0.00160779,0.007664716,0.00001273437,0.00004504067,0.0005950278,0.00006326946,0.001332031,0.9852952,0.00005662321,0.003058044,0.00001097718],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965039,0.001442167,0.0009017157,0.0001376486,0.00007785115,0.0000182685,0.0002208042,0.00004314431,0.000654533],"genre_scores_gemma":[0.9947059,0.0009878938,0.001106947,0.0001062291,0.00003388197,0.00005563374,0.0004078521,0.00001678707,0.00257887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002002129,"threshold_uncertainty_score":0.006697774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02792158878583336,"score_gpt":0.3085878951279713,"score_spread":0.280666306342138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}