{"id":"W2801801585","doi":"10.1016/j.jaci.2018.04.029","title":"Neutropenia among patients with adenosine deaminase deficiency","year":2018,"lang":"en","type":"letter","venue":"Journal of Allergy and Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's Hospital of Eastern Ontario; SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Adenosine deaminase; Purine nucleoside phosphorylase; Adenosine deaminase deficiency; Severe combined immunodeficiency; Enzyme replacement therapy; Immunology; Immunodeficiency; Medicine; Hematopoietic stem cell transplantation; Internal medicine; Transplantation; Biology; Immune system; Purine; Adenosine; Enzyme; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0007107547,0.0006274535,0.00155628,0.0003595505,0.0003983133,0.00005084369,0.001075483,0.00264441,0.0008249356],"category_scores_gemma":[0.0003355846,0.0004414036,0.000480863,0.0002216939,0.00350326,0.0002847866,0.0002924555,0.005244812,0.0002073905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004563345,"about_ca_system_score_gemma":0.0002859347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005676469,"about_ca_topic_score_gemma":0.00001418906,"domain_scores_codex":[0.9953753,0.0008956539,0.002121206,0.0005924142,0.0001561165,0.0008593511],"domain_scores_gemma":[0.9955783,0.0006583819,0.002303378,0.000623067,0.0008140571,0.00002275963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008257223,0.004691277,0.03212054,0.0001359283,0.01988214,0.001161143,0.0007719828,0.000006137192,0.0007455954,0.0002485444,0.8885634,0.04341611],"study_design_scores_gemma":[0.006552733,0.006722078,0.2080498,0.0002770025,0.0004936911,0.0003074089,0.0001218083,4.978021e-7,0.00007656308,0.000105231,0.776702,0.0005912013],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8969563,0.06074217,0.00007087087,0.03470862,0.006066373,0.000359856,0.00003707198,0.0000454462,0.001013257],"genre_scores_gemma":[0.7848243,0.0166083,0.000215318,0.1833498,0.001037928,0.00002441531,0.001023849,0.0003284939,0.0125877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1759293,"threshold_uncertainty_score":0.9998038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016619108772392,"score_gpt":0.2445516661485861,"score_spread":0.2343854750608622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}