{"id":"W2801806511","doi":"10.1161/atvb.37.suppl_1.146","title":"Abstract 146: Deficiency of Cystathionine beta Synthase Alters Blood Brain Barrier Integrity and Exacerbates Cerebral Ischemia Reperfusion Injury in Mice","year":2017,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kruger (Canada)","funders":"","keywords":"Cystathionine beta synthase; Hyperhomocysteinemia; Blood–brain barrier; Evans Blue; Medicine; Extravasation; Homocysteine; Endocrinology; Internal medicine; Ischemia; Stroke (engine); GLUT3; Reperfusion injury; Anesthesia; Chemistry; Pathology; GLUT1; Glucose transporter; Methionine; Biochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003440488,0.001039259,0.0008097409,0.001082493,0.000378086,0.0007230152,0.0006973067,0.001078895,0.006419],"category_scores_gemma":[0.0001430712,0.0006161137,0.0007476129,0.0004135595,0.0007161174,0.0005261166,0.0004627974,0.001681864,0.00282756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004235336,"about_ca_system_score_gemma":0.0002866059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006240791,"about_ca_topic_score_gemma":0.0006792824,"domain_scores_codex":[0.9995067,0.00005430052,0.00008026299,0.0001387306,0.0001089823,0.0001109069],"domain_scores_gemma":[0.9995529,0.00002877614,0.0001610968,0.00004531243,0.00003260484,0.0001791998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000631469,0.0001519136,0.000182606,0.00005464911,0.0000124703,0.0001343419,0.00003257887,0.00003259951,0.9975555,0.0001279143,0.0001220304,0.0009619222],"study_design_scores_gemma":[0.0002282559,0.002078504,0.007724202,0.00004707578,0.00007992402,0.001431171,0.00007658546,0.0006824152,0.9827601,0.0001826965,0.004690187,0.00001901415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820614,0.002220481,0.006096452,0.0007055069,0.0001385481,0.0001637678,0.003705238,0.0007385667,0.004170022],"genre_scores_gemma":[0.9510918,0.003328936,0.009065069,0.000479006,0.00009449843,0.0005272449,0.004442441,0.0004953919,0.03047556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006419,"threshold_uncertainty_score":0.02147371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03584299998447512,"score_gpt":0.3266222958120195,"score_spread":0.2907792958275444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}