{"id":"W2801862113","doi":"10.1016/j.bbrc.2018.04.066","title":"Visceral adipose tissue-derived serine protease inhibitor accelerates cholesterol efflux by up-regulating ABCA1 expression via the NF-κB/miR-33a pathway in THP-1 macropahge-derived foam cells","year":2018,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Alberta; University of Calgary","funders":"Construct Program of the Key Discipline in Hunan Province; University of South China; National Natural Science Foundation of China","keywords":"ABCA1; Efflux; Foam cell; Adipose tissue; Endocrinology; Chemistry; Serine protease; Internal medicine; Cholesterol; Inflammation; Serine; Phosphorylation; Cell biology; Biology; Protease; Biochemistry; Transporter; Lipoprotein; Medicine; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000208768,0.0003394202,0.0003477921,0.0002954598,0.0001754101,0.0003683469,0.0001101241,0.0002080751,0.001929636],"category_scores_gemma":[0.0001370349,0.0002358283,0.0003914456,0.0001780629,0.0002779324,0.0002301858,0.0002318754,0.0008964732,0.0004767199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001692553,"about_ca_system_score_gemma":0.0002419427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005525671,"about_ca_topic_score_gemma":0.0007912905,"domain_scores_codex":[0.9998286,0.00002914132,0.00001712522,0.00002508519,0.00003945618,0.00006052796],"domain_scores_gemma":[0.9999256,0.00001190815,0.00002036531,0.000009711395,0.00001032676,0.00002201771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007437939,0.00006961068,0.00039248,0.00006908637,0.00001452076,0.000131997,0.00002613751,0.00003539057,0.996458,0.0001053861,0.0001576557,0.001795978],"study_design_scores_gemma":[0.0001471369,0.0006065261,0.01432105,0.000009037483,0.00008231843,0.0005982851,0.0001288594,0.001095688,0.9792829,0.0001567995,0.003559982,0.00001142831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915138,0.002547749,0.003303462,0.0003579374,0.0001168536,0.00003471437,0.0006186739,0.0001548274,0.001351963],"genre_scores_gemma":[0.9939566,0.001194005,0.001895612,0.0001394775,0.00003215452,0.0000440063,0.000502969,0.0000236184,0.002211537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001929636,"threshold_uncertainty_score":0.006455302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04552971810779885,"score_gpt":0.3469290851086455,"score_spread":0.3013993670008466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}