{"id":"W2802058432","doi":"10.1111/all.13466","title":"Evaluation of avoralstat, an oral kallikrein inhibitor, in a Phase 3 hereditary angioedema prophylaxis trial: The <scp>OPuS</scp>‐2 study","year":2018,"lang":"en","type":"article","venue":"Allergy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"BioCryst","keywords":"Hereditary angioedema; Placebo; Angioedema; Medicine; Kallikrein; C1-inhibitor; Randomized controlled trial; Internal medicine; Clinical endpoint; Gastroenterology; Anesthesia; Surgery; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001476745,0.0008919362,0.001077629,0.0002433384,0.0002300375,0.0006797185,0.0004233404,0.0006916213,0.002396277],"category_scores_gemma":[0.0006135271,0.0002482931,0.0008907689,0.0002074663,0.0003889518,0.0003562907,0.0001642727,0.001353782,0.0002796111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004517572,"about_ca_system_score_gemma":0.0009109357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006328434,"about_ca_topic_score_gemma":0.001477133,"domain_scores_codex":[0.9996666,0.0002075013,0.00001232194,0.00003204338,0.0000375548,0.00004405881],"domain_scores_gemma":[0.9995659,0.0001054862,0.0001139562,0.00002433447,0.00003165604,0.0001586905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8788365,0.01681767,0.005901427,0.001184526,0.001298749,0.0002580269,0.0001379395,0.001305246,0.01757181,0.0003091298,0.002873234,0.07350569],"study_design_scores_gemma":[0.818225,0.1640228,0.0128132,0.00007284108,0.000488579,0.0002017127,0.00002534974,0.001060306,0.001535208,0.0001561613,0.001382636,0.0000161815],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938688,0.003160724,0.000257483,0.0003024906,0.00007514852,0.0007871739,0.0004218987,0.00005566284,0.001070727],"genre_scores_gemma":[0.9929818,0.002189713,0.0008445246,0.000544278,0.0001456772,0.001212303,0.0009115106,0.00001214248,0.001157982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002396277,"threshold_uncertainty_score":0.008016348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07372628750905459,"score_gpt":0.3693226557572599,"score_spread":0.2955963682482053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}