{"id":"W2802058432","doi":"10.1111/all.13466","title":"Evaluation of avoralstat, an oral kallikrein inhibitor, in a Phase 3 hereditary angioedema prophylaxis trial: The <scp>OPuS</scp>‐2 study","year":2018,"lang":"en","type":"article","venue":"Allergy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"BioCryst","keywords":"Hereditary angioedema; Placebo; Angioedema; Medicine; Kallikrein; C1-inhibitor; Randomized controlled trial; Internal medicine; Clinical endpoint; Gastroenterology; Anesthesia; Surgery; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003289725,0.0002834277,0.0005462692,0.0002519753,0.0001380845,0.00003256619,0.0002331493,0.000153081,0.0002175969],"category_scores_gemma":[0.0008805567,0.000207805,0.0001576652,0.000662295,0.0002263578,0.0002760655,0.00007193856,0.0001751298,0.00002422292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001138906,"about_ca_system_score_gemma":0.000515287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002041074,"about_ca_topic_score_gemma":0.004899832,"domain_scores_codex":[0.996177,0.0007357388,0.0008328679,0.0005066881,0.001345983,0.0004017256],"domain_scores_gemma":[0.9978815,0.0002108446,0.0002857762,0.0007198672,0.0007401698,0.0001618223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.02613214,0.05659257,0.07705142,0.0002473881,0.003811373,0.0004308043,0.1042023,0.0005030167,0.01638993,0.001487882,0.05100257,0.6621487],"study_design_scores_gemma":[0.42499,0.09700134,0.3583562,0.0005619101,0.001809655,0.0001081821,0.02833389,0.03443598,0.02020868,0.006713552,0.02674984,0.000730718],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943341,0.001255004,0.00002053019,0.0001904684,0.0007409149,0.00265161,0.00001221071,0.00007212062,0.0007230469],"genre_scores_gemma":[0.997628,0.00002109659,0.0001308648,0.0001907672,0.00133755,0.0001832426,0.0000916894,0.00005030509,0.0003664624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.661418,"threshold_uncertainty_score":0.8474044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07372628750905459,"score_gpt":0.3693226557572599,"score_spread":0.2955963682482053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}