{"id":"W2802068594","doi":"10.1038/s41467-018-02875-z","title":"Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":292,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; McMaster University","funders":"Canada Research Chairs; Ontario Research Foundation","keywords":"Colistin; MCR-1; Antibiotics; Microbiology; Klebsiella pneumoniae; Bacteria; Enterobacteriaceae; Gram-negative bacteria; Polymyxin; Biology; Drug resistance; Antibiotic resistance; Combination therapy; Medicine; Pharmacology; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001859382,0.0004157622,0.0005166887,0.0002924613,0.0001066048,0.0003186323,0.0002588592,0.0002667911,0.0006546988],"category_scores_gemma":[0.0002301472,0.0001421602,0.0002456808,0.0001823223,0.0001860247,0.0002317704,0.0002782683,0.0006337509,0.0001846303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002766106,"about_ca_system_score_gemma":0.0001979931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004986856,"about_ca_topic_score_gemma":0.001387493,"domain_scores_codex":[0.9997328,0.00007546622,0.00002491808,0.00003654511,0.00007297756,0.00005731255],"domain_scores_gemma":[0.9998832,0.00002361114,0.00004066126,0.00001711107,0.00001026852,0.00002518035],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001150233,0.00009367245,0.0001427998,0.00006902239,0.000008408631,0.00005276005,0.00001427037,0.0001939293,0.9945674,0.00006696046,0.00006038029,0.004615429],"study_design_scores_gemma":[0.00002794004,0.001638593,0.001845599,0.00001453188,0.00002033263,0.0004382374,0.00001481755,0.001131965,0.9913386,0.00003434352,0.003486606,0.000008503656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881811,0.00623691,0.003190458,0.0002540884,0.00007222836,0.00007894282,0.0001330732,0.0001099833,0.001743347],"genre_scores_gemma":[0.9906771,0.00253261,0.005261702,0.00005760405,0.0000305782,0.00003008513,0.0001831337,0.00001679617,0.001210417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006546988,"threshold_uncertainty_score":0.002190173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01190982393986372,"score_gpt":0.281360923309424,"score_spread":0.2694510993695602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}