{"id":"W2802093561","doi":"10.1371/journal.ppat.1006996","title":"Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Parasite Biology and Host Interactions","field":"Environmental Science","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; University of Minnesota","keywords":"Biology; Haemonchus contortus; Caenorhabditis elegans; Levamisole; Cholinergic; Nematode; Pyrantel; Acetylcholine receptor; Anthelmintic; Nematode infection; Gene; Genetics; Receptor; Immunology; Neuroscience; Zoology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002570562,0.0001407883,0.0001863374,0.00003207033,0.0002520971,0.00002460808,0.0001308865,0.0000719026,0.00007994717],"category_scores_gemma":[0.00005316564,0.00008635072,0.00004550933,0.000109585,0.0006043909,0.0001371138,0.00008056463,0.0001226726,0.00002157114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003675058,"about_ca_system_score_gemma":0.00001135839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001205376,"about_ca_topic_score_gemma":0.0006782959,"domain_scores_codex":[0.9990153,0.0001126034,0.0002271161,0.0002605451,0.0001735819,0.0002108568],"domain_scores_gemma":[0.9993765,0.000244403,0.0001108471,0.0002147137,0.00001428278,0.00003920747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001410727,0.00009375539,0.8407127,0.000006901105,0.00002641895,0.000004003089,0.001018616,0.0007569033,0.156748,0.0001839089,0.000005433151,0.0004291862],"study_design_scores_gemma":[0.0001230698,0.00003644468,0.9061365,0.00002499458,0.00006888282,0.00003009555,0.0001589496,0.03786533,0.05504448,0.0003934982,0.000008169949,0.000109649],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925607,0.00001953591,0.006414054,0.0002179302,0.00004513799,0.000189584,0.00007663092,0.00001142936,0.0004650272],"genre_scores_gemma":[0.9992021,0.00001009576,0.0005385101,0.00003856694,0.00006231965,0.00002583953,0.000009619023,0.000008558372,0.0001043651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1017036,"threshold_uncertainty_score":0.352128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06557080361927073,"score_gpt":0.274547191962612,"score_spread":0.2089763883433413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}