{"id":"W2802093561","doi":"10.1371/journal.ppat.1006996","title":"Deciphering the molecular determinants of cholinergic anthelmintic sensitivity in nematodes: When novel functional validation approaches highlight major differences between the model Caenorhabditis elegans and parasitic species","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Parasite Biology and Host Interactions","field":"Environmental Science","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Biotechnology and Biological Sciences Research Council; Directorate for Biological Sciences; University of Minnesota","keywords":"Biology; Haemonchus contortus; Caenorhabditis elegans; Levamisole; Cholinergic; Nematode; Pyrantel; Acetylcholine receptor; Anthelmintic; Nematode infection; Gene; Genetics; Receptor; Immunology; Neuroscience; Zoology; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001695468,0.0002860201,0.00019972,0.0001970024,0.0001691344,0.0002772609,0.0002812886,0.000352572,0.0008810179],"category_scores_gemma":[0.0002294312,0.00009954636,0.0001975435,0.00008808275,0.0002931944,0.0003521345,0.0001748915,0.0004917397,0.0002678932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003020652,"about_ca_system_score_gemma":0.0001960897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001228208,"about_ca_topic_score_gemma":0.001913639,"domain_scores_codex":[0.9999087,0.00001134471,0.00001008063,0.00001737637,0.00003286426,0.00001955564],"domain_scores_gemma":[0.9998739,0.00002999784,0.00003327572,0.00001709134,0.00002570833,0.00001996415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000102333,0.000004676622,0.0001446733,0.00001470207,0.000001406424,0.00001090573,0.00000466695,0.00001522227,0.9994199,0.00002868688,0.000002765263,0.0003420464],"study_design_scores_gemma":[0.000005450752,0.0002400755,0.01372344,0.000008741124,0.00001857186,0.0003272949,0.00006387033,0.001002822,0.9829501,0.00006799714,0.001586435,0.000005314197],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927338,0.0007829304,0.004870648,0.0001137193,0.00001100949,0.00004771795,0.0003073957,0.00004530715,0.001087284],"genre_scores_gemma":[0.9890204,0.001012061,0.007872811,0.00008166131,0.000006482946,0.00004288521,0.0006117343,0.00002153081,0.001330438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001228208,"threshold_uncertainty_score":0.002947271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06557080361927073,"score_gpt":0.274547191962612,"score_spread":0.2089763883433413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}