{"id":"W2802198289","doi":"10.1084/jem.20171207","title":"<i>PTEN</i> deletion in luminal cells of mature prostate induces replication stress and senescence in vivo","year":2018,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Association pour la Recherche sur les Tumeurs de la Prostate; Centre National de la Recherche Scientifique; Ministère de l'Enseignement Supérieur et de la Recherche; China Scholarship Council; Ligue Contre le Cancer; Université de Strasbourg; Institute of Genetics; Institut National de la Santé et de la Recherche Médicale; Fondation ARC pour la Recherche sur le Cancer; Agence Nationale de la Recherche","keywords":"In vivo; Senescence; PTEN; Replication (statistics); Cell biology; Prostate; Biology; Cancer research; Chemistry; Genetics; Virology; Signal transduction; Cancer; PI3K/AKT/mTOR pathway","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001760557,0.0002651618,0.0002327887,0.000405667,0.0001780768,0.0003436514,0.0001862524,0.0002169357,0.001397564],"category_scores_gemma":[0.0001177585,0.0002534302,0.0002398702,0.0002091326,0.0002376838,0.0002288902,0.0002294688,0.00064444,0.0004778286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001691749,"about_ca_system_score_gemma":0.0002464811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004802093,"about_ca_topic_score_gemma":0.0006653097,"domain_scores_codex":[0.9998357,0.00002565788,0.00001668479,0.00002954265,0.00004083828,0.00005146418],"domain_scores_gemma":[0.9997439,0.00003434267,0.00006694848,0.00003224202,0.00001109805,0.0001114669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001516409,0.00004341077,0.0002441743,0.0000111493,0.000003388605,0.00006140974,0.00001053485,0.00003356134,0.9988055,0.0001010537,0.00002474868,0.0005094262],"study_design_scores_gemma":[0.00002464668,0.001057881,0.007935668,0.000004668776,0.00001512946,0.0006960854,0.00004521443,0.0009215163,0.987691,0.00006825171,0.001534831,0.000005232548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968106,0.0005378464,0.00126892,0.00005050876,0.00001458439,0.00001573016,0.0002493691,0.00008689916,0.0009655099],"genre_scores_gemma":[0.9961048,0.0004220567,0.0007607646,0.00003584565,0.000009757186,0.00002198816,0.000554678,0.00003117545,0.002058896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001397564,"threshold_uncertainty_score":0.004675269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01587881463438515,"score_gpt":0.2993812328077579,"score_spread":0.2835024181733727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}