{"id":"W2802228122","doi":"10.1016/j.psychres.2018.04.064","title":"DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic–pituitary–adrenal axis activity and to early life emotional abuse","year":2018,"lang":"en","type":"article","venue":"Psychiatry Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":143,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University; Centre Hospitalier Universitaire Sainte-Justine; McGill University","funders":"Health Research Board","keywords":"DNA methylation; Glucocorticoid receptor; FKBP5; Methylation; Endocrinology; Exon; Internal medicine; Epigenetics; Biology; Glucocorticoid; Hypothalamic–pituitary–adrenal axis; Gene; Genetics; Medicine; Hormone; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008774249,0.0001337464,0.0001282618,0.000249248,0.000270279,0.00005790163,0.0001470087,0.0001625638,0.0001076654],"category_scores_gemma":[0.0002911887,0.0001098553,0.00003740159,0.0005080857,0.0001009157,0.00001541558,0.0001737498,0.0002370607,0.00006378663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005761114,"about_ca_system_score_gemma":0.0001338778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001852423,"about_ca_topic_score_gemma":0.003520823,"domain_scores_codex":[0.9980315,0.0004183351,0.0002761404,0.000533871,0.0004186139,0.0003215357],"domain_scores_gemma":[0.9991615,0.00009841657,0.00005974344,0.0003190721,0.0002068642,0.0001543874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003257107,0.00008475496,0.4702507,0.000005530987,0.00001466296,2.104931e-7,0.0002277802,0.0002618206,0.52737,0.00002245964,0.0001964736,0.001239876],"study_design_scores_gemma":[0.0004514146,0.0003481043,0.9376438,0.00003125417,0.000003117194,0.000001133485,0.00008240314,0.0003778553,0.06030815,0.0003865187,0.0002417383,0.000124499],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955721,0.000639094,0.0006126952,0.002082468,0.0003235843,0.000592545,0.00003163666,0.000005726415,0.0001400711],"genre_scores_gemma":[0.9981943,0.0001273208,0.0006419619,0.00008509425,0.0002922231,0.00009403368,0.00007193629,0.00001672781,0.0004763982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4673932,"threshold_uncertainty_score":0.4479771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03787238490934768,"score_gpt":0.3246986848443715,"score_spread":0.2868262999350238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}