{"id":"W2802233748","doi":"10.1016/j.jcyt.2018.02.012","title":"BCMA-specific TAC receptor-engineered T cells for multiple myeloma","year":2018,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chimeric antigen receptor; Receptor; Antigen; Cell biology; Cancer research; T cell; Biology; Immunology; Molecular biology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003682982,0.0002559288,0.000401933,0.0001969124,0.0001484598,0.00004980317,0.0002306943,0.000185404,0.01390307],"category_scores_gemma":[0.00004455672,0.0002274047,0.0002311848,0.0003375717,0.0002204222,0.00006922066,0.00002096455,0.0002152934,0.0008054469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001706046,"about_ca_system_score_gemma":0.00009647474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000129313,"about_ca_topic_score_gemma":0.000008064697,"domain_scores_codex":[0.9981954,0.00004717549,0.0002994487,0.0004751171,0.0003758781,0.0006069416],"domain_scores_gemma":[0.9983799,0.0002613345,0.00005790871,0.0007308386,0.0003202995,0.0002496701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001853177,0.0001410618,0.000264896,0.00003244622,0.0001042857,0.000004310784,0.0005316191,0.000001426018,0.8595345,0.0001057337,0.06861139,0.06881517],"study_design_scores_gemma":[0.003388942,0.0008271105,0.0005246227,0.00002664474,0.000005673431,0.000006994955,0.00004861499,0.000304632,0.4552283,0.00005054823,0.539441,0.0001469632],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9658515,0.001926984,0.01406504,0.002535434,0.002038907,0.003893806,0.0001290188,0.0005703446,0.008988893],"genre_scores_gemma":[0.8578776,0.002076268,0.02190021,0.002053996,0.007566612,0.000487287,0.000145897,0.0004304189,0.1074617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4708296,"threshold_uncertainty_score":0.9999725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04063145682494303,"score_gpt":0.309194271359947,"score_spread":0.268562814535004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}