{"id":"W2802233748","doi":"10.1016/j.jcyt.2018.02.012","title":"BCMA-specific TAC receptor-engineered T cells for multiple myeloma","year":2018,"lang":"en","type":"article","venue":"Cytotherapy","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Chimeric antigen receptor; Receptor; Antigen; Cell biology; Cancer research; T cell; Biology; Immunology; Molecular biology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392474,0.0002847684,0.0001755046,0.0002816608,0.0002056394,0.000425109,0.0002864308,0.0004548849,0.00168798],"category_scores_gemma":[0.0001303474,0.0001152047,0.0001629978,0.0001838079,0.0001830577,0.0002413161,0.0002148646,0.0008311686,0.0004515624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004387245,"about_ca_system_score_gemma":0.0002871266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009746,"about_ca_topic_score_gemma":0.001150996,"domain_scores_codex":[0.9998964,0.00001721399,0.000005432638,0.00002195,0.00003284926,0.00002607878],"domain_scores_gemma":[0.9999708,0.000006770344,0.000006121918,0.000005622863,0.000004688178,0.000006051028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000169724,0.0001689941,0.0001096713,0.00007858227,0.00001233446,0.00007584417,0.00003664627,0.0007155322,0.9793388,0.001299056,0.0005640772,0.01743063],"study_design_scores_gemma":[0.00008307381,0.0005540875,0.0005571743,0.00001251053,0.00004493286,0.0004146713,0.00001702724,0.003175312,0.9787733,0.0003034995,0.01605768,0.00000675611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9219049,0.01669511,0.0430527,0.0009837153,0.0004742317,0.0003051629,0.0004267878,0.0008898674,0.01526753],"genre_scores_gemma":[0.9891428,0.001851734,0.00531618,0.0001228322,0.00002755526,0.00006680515,0.0001224976,0.00002874312,0.003320688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00168798,"threshold_uncertainty_score":0.005646825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04063145682494303,"score_gpt":0.309194271359947,"score_spread":0.268562814535004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}