{"id":"W2802249086","doi":"10.4155/bio-2018-0014","title":"11th GCC Closed Forum: Cumulative Stability; Matrix Stability; Immunogenicity assays; Laboratory Manuals; Biosimilars; Chiral methods; Hybrid LBA/LCMS Assays; Fit-for-Purpose Validation; China Food and Drug Administration Bioanalytical Method Validation","year":2018,"lang":"en","type":"article","venue":"Bioanalysis","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pharma Medica Research (Canada); inVentiv Health Clinical; Grand Challenges Canada","funders":"","keywords":"Bioanalysis; Immunogenicity; Biosimilar; Food and drug administration; Medical education; Computer science; Chemistry; Medicine; Pharmacology; Chromatography; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02452509,0.002162341,0.00121131,0.004238557,0.005094209,0.009886103,0.003044668,0.01416418,0.1130857],"category_scores_gemma":[0.020357,0.0008925501,0.0009630081,0.001963303,0.003893767,0.004470041,0.006712731,0.006372809,0.04258216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006762896,"about_ca_system_score_gemma":0.01148706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007459534,"about_ca_topic_score_gemma":0.01774034,"domain_scores_codex":[0.9891977,0.002999054,0.0006607923,0.001113976,0.004679004,0.001349426],"domain_scores_gemma":[0.9663175,0.008304343,0.002941448,0.001758817,0.01445152,0.006226317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009938684,0.0001654784,0.0005636026,0.0002768598,0.000005481258,0.00028389,0.0002737684,0.0001729765,0.002592243,0.009937813,0.9195666,0.06606191],"study_design_scores_gemma":[0.00001232938,0.00008995501,0.001075014,0.0001749397,0.000004686528,0.0001378116,0.0001263645,0.0002143913,0.001050995,0.001873642,0.9952167,0.00002316636],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.00987934,0.02731416,0.04128294,0.1744845,0.1123853,0.003275568,0.005590585,0.004875523,0.6209121],"genre_scores_gemma":[0.02016196,0.004559787,0.01333407,0.03581906,0.02403862,0.000909774,0.003309198,0.001483796,0.8963838],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1130857,"threshold_uncertainty_score":0.3783092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03864693967655648,"score_gpt":0.3664458933095864,"score_spread":0.32779895363303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}