{"id":"W2802259607","doi":"10.1371/journal.pgen.1007383","title":"Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration","year":2018,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Down syndrome and intellectual disability research","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University College London Hospitals NHS Foundation Trust; National Institutes of Health; Cancer Research UK; Brain Research Trust; Brain Research UK; NIHR Oxford Biomedical Research Centre; Wellcome Trust; Francis Crick Institute; National Institute of Neurological Disorders and Stroke; National Institute for Health and Care Research; Alzheimer Society; Medical Research Council; Wellcome","keywords":"Biology; Motor neuron; Neuroscience; Degeneration (medical); Medicine; Pathology; Spinal cord","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001141107,0.0003513643,0.0002013802,0.0008344825,0.000112645,0.0001747932,0.0001310227,0.0002621458,0.00192651],"category_scores_gemma":[0.0001974911,0.0001277079,0.0002087569,0.0002685509,0.0001798158,0.00009804236,0.0002779509,0.0002210426,0.0003244526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001293629,"about_ca_system_score_gemma":0.0000815813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006939509,"about_ca_topic_score_gemma":0.0009656505,"domain_scores_codex":[0.9998996,0.00001524076,0.00001454142,0.00002681253,0.00002721856,0.0000165477],"domain_scores_gemma":[0.9998876,0.00003021145,0.00002617168,0.000009159234,0.00001198692,0.00003478544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001505896,0.00001459417,0.005804016,0.00004791995,0.00001858265,0.001199982,0.00002510358,0.00004759908,0.9899842,0.00007061351,0.00005247816,0.002584319],"study_design_scores_gemma":[0.00003494323,0.0007059133,0.3708188,0.00003957993,0.0001661842,0.01928462,0.0001395322,0.001319922,0.6018184,0.000212371,0.005440879,0.00001889266],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931256,0.0008877871,0.002829855,0.00005254762,0.00002237213,0.00002418908,0.001373947,0.00007209647,0.001611587],"genre_scores_gemma":[0.9930051,0.0009495817,0.003107768,0.00006587441,0.000005372799,0.00002202881,0.001139595,0.00002945797,0.001675426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00192651,"threshold_uncertainty_score":0.006444812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05109803756810768,"score_gpt":0.3108485461818181,"score_spread":0.2597505086137104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}