{"id":"W2802280025","doi":"10.1128/jvi.00484-18","title":"Incomplete Downregulation of CD4 Expression Affects HIV-1 Env Conformation and Antibody-Dependent Cellular Cytotoxicity Responses","year":2018,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; Government of Canada","keywords":"Antibody-dependent cell-mediated cytotoxicity; Biology; Downregulation and upregulation; Epitope; Antibody; Virology; Glycoprotein; Reporter gene; Molecular biology; Cytotoxicity; Gene; Immunology; Gene expression; In vitro; Genetics; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000207263,0.0002597564,0.000279273,0.0001184787,0.0001078878,0.000330915,0.0001994773,0.0003179292,0.0009792504],"category_scores_gemma":[0.0002676466,0.0001325676,0.0001638058,0.0001380614,0.0001892381,0.0001910453,0.0001422485,0.0006487315,0.0002286832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003171352,"about_ca_system_score_gemma":0.0001214797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000690406,"about_ca_topic_score_gemma":0.0005538366,"domain_scores_codex":[0.9997571,0.00005583809,0.00002662765,0.00003187732,0.00004566177,0.00008290363],"domain_scores_gemma":[0.9998109,0.00006325031,0.00003322254,0.00002926758,0.00002801129,0.00003541472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001176093,0.00005380962,0.0002248665,0.00001505213,0.000003391916,0.00001270107,0.000006823037,0.00008931248,0.9989675,0.00002268828,0.00001578111,0.0004704642],"study_design_scores_gemma":[0.000008940939,0.0003759911,0.002767425,0.000002946048,0.00000971074,0.00005319223,0.00001239098,0.0007515858,0.9956667,0.000008803153,0.0003401009,0.000002160006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985982,0.0003712916,0.0004719151,0.0000198062,0.000007165734,0.00001139645,0.0001092943,0.00001454344,0.000396572],"genre_scores_gemma":[0.9985059,0.000167517,0.0003981192,0.00002567267,0.000003117795,0.00001744161,0.0002490385,0.000007222701,0.0006259353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009792504,"threshold_uncertainty_score":0.003275871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01382011241215952,"score_gpt":0.2833371909352436,"score_spread":0.269517078523084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}