{"id":"W2802319445","doi":"10.1038/s41419-018-0544-7","title":"N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis","year":2018,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vlaamse regering; Universiteit Gent; Fonds Wetenschappelijk Onderzoek; Institut National Du Cancer; Vlaams Instituut voor Biotechnologie; University of Toronto; Medical Research Council; Belgian Federal Science Policy Office","keywords":"Apoptosis; Ectodomain; Unfolded protein response; Tunicamycin; Cell biology; Endoplasmic reticulum; Programmed cell death; Cytotoxic T cell; Tumor necrosis factor alpha; Glycosylation; Caspase; Biology; Chemistry; Receptor; Immunology; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007147076,0.0001233334,0.0001010366,0.0000419866,0.00008439108,0.00001534533,0.00006548921,0.00009956057,0.00004004832],"category_scores_gemma":[0.00003526335,0.0001127025,0.00007374158,0.00005136158,0.00005757065,0.00000571366,0.00003051037,0.00003061438,0.000005144892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004748485,"about_ca_system_score_gemma":0.00007274732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000015622,"about_ca_topic_score_gemma":0.000007743693,"domain_scores_codex":[0.9992755,0.00002725708,0.0001617792,0.0002735969,0.0001013013,0.0001605708],"domain_scores_gemma":[0.9993389,0.00000496438,0.00006833608,0.0002335088,0.00007057727,0.0002837697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001898328,0.00009150745,0.0007705903,0.00004290298,0.00001028122,8.05583e-7,0.00005097234,0.000006485464,0.9929433,0.00044101,0.0002242405,0.005228018],"study_design_scores_gemma":[0.001011486,0.0004819919,0.02053089,0.0000129797,0.00007486213,0.000001295378,0.0000496806,0.000596869,0.972838,0.0006961167,0.0034661,0.0002396701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995846,0.0002970429,0.001822478,0.00004661715,0.00008812117,0.0001666366,0.00004110842,0.00001172318,0.001680232],"genre_scores_gemma":[0.9976902,0.0001594091,0.000415077,0.00009546518,0.0002160904,0.000008548865,0.0001647111,0.00001649134,0.001233994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02010529,"threshold_uncertainty_score":0.4595876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400201581963137,"score_gpt":0.2372255391420606,"score_spread":0.2232235233224292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}