{"id":"W2802319445","doi":"10.1038/s41419-018-0544-7","title":"N-glycosylation of mouse TRAIL-R restrains TRAIL-induced apoptosis","year":2018,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Vlaamse regering; Universiteit Gent; Fonds Wetenschappelijk Onderzoek; Institut National Du Cancer; Vlaams Instituut voor Biotechnologie; University of Toronto; Medical Research Council; Belgian Federal Science Policy Office","keywords":"Apoptosis; Ectodomain; Unfolded protein response; Tunicamycin; Cell biology; Endoplasmic reticulum; Programmed cell death; Cytotoxic T cell; Tumor necrosis factor alpha; Glycosylation; Caspase; Biology; Chemistry; Receptor; Immunology; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001800246,0.0003836031,0.0003688501,0.0001847985,0.0001258551,0.0002703018,0.0002728252,0.0002639211,0.0005654242],"category_scores_gemma":[0.0001681673,0.0001495116,0.0003640548,0.0001942131,0.0002179312,0.0002185319,0.0002020797,0.0007300656,0.0004158256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004384561,"about_ca_system_score_gemma":0.0003246419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007188743,"about_ca_topic_score_gemma":0.000826814,"domain_scores_codex":[0.9997606,0.00004250598,0.00004736466,0.00003555656,0.00005580692,0.00005827053],"domain_scores_gemma":[0.9997893,0.00003400326,0.00005897175,0.0000483495,0.00002359348,0.00004580713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001144034,0.00006234377,0.00008193878,0.00001825798,0.000004305023,0.00002936912,0.00001085333,0.00005443562,0.9990975,0.00004785266,0.00002502929,0.0004537213],"study_design_scores_gemma":[0.00002921006,0.0004948407,0.001175542,0.000006831528,0.0000162159,0.0002685331,0.00001325136,0.0007211511,0.9958247,0.00002560407,0.001420149,0.000003919722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961734,0.0007897457,0.001557132,0.00007449354,0.00002433385,0.00004407703,0.000252973,0.0001001473,0.0009836792],"genre_scores_gemma":[0.9938642,0.0007679166,0.002230733,0.0000714597,0.0000122751,0.00004569954,0.0009532595,0.00003569713,0.002018762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007188743,"threshold_uncertainty_score":0.003181219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01400201581963137,"score_gpt":0.2372255391420606,"score_spread":0.2232235233224292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}