{"id":"W2802340312","doi":"10.1016/j.jconrel.2018.04.029","title":"Hyperthermia-mediated drug delivery induces biological effects at the tumor and molecular levels that improve cisplatin efficacy in triple negative breast cancer","year":2018,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Cisplatin; Hyperthermia; Breast cancer; Triple-negative breast cancer; Cancer research; In vivo; Clonogenic assay; Medicine; Doxorubicin; Cancer; Pharmacology; Chemotherapy; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005536,0.0001241755,0.0001573317,0.0001388368,0.00009521913,0.0001471436,0.00009230425,0.0001378878,0.000905884],"category_scores_gemma":[0.0001040161,0.0001211622,0.0001219018,0.00008195003,0.0001522058,0.0001377311,0.0001085545,0.0002833888,0.0001269326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002119326,"about_ca_system_score_gemma":0.0001346549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005390738,"about_ca_topic_score_gemma":0.0008869852,"domain_scores_codex":[0.9999471,0.000008813797,0.000004435822,0.000009536388,0.0000155975,0.00001456121],"domain_scores_gemma":[0.9999727,0.000006531338,0.000006716555,0.000003665468,0.000003939597,0.000006461823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001665909,0.00003591352,0.00006636871,0.00001680363,0.00000315095,0.00001222886,0.00001537954,0.0001367541,0.9977483,0.00008661462,0.00005048054,0.001661336],"study_design_scores_gemma":[0.00002520492,0.0004225433,0.001888876,0.000001543048,0.0000128454,0.00006930644,0.000007098914,0.0007385144,0.996076,0.00002062596,0.0007345472,0.000002924373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968932,0.0007226735,0.001414349,0.00005391186,0.0000175606,0.00002034828,0.00004074723,0.00003390768,0.0008033406],"genre_scores_gemma":[0.9982476,0.0002783877,0.0005036994,0.00001516442,0.000004702419,0.00001334078,0.00003473653,0.00000955724,0.0008927749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000905884,"threshold_uncertainty_score":0.003030419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134597216195206,"score_gpt":0.2428466577256011,"score_spread":0.2315006855636491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}