{"id":"W2802350433","doi":"10.3390/ph11020035","title":"Research Progress on Rolling Circle Amplification (RCA)-Based Biomedical Sensing","year":2018,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cape Breton University","funders":"National Natural Science Foundation of China; Huaihai Institute of Technology","keywords":"Rolling circle replication; Deoxyribozyme; Nuclease; Biosensor; Aptamer; DNA; Nucleic acid; Computational biology; Nanotechnology; RNA; Surface plasmon resonance; Biology; Molecular biology; Materials science; Gene; Genetics; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008337744,0.001048473,0.001024288,0.002423272,0.0003549461,0.0009314643,0.0008788103,0.001025404,0.002711876],"category_scores_gemma":[0.0007987303,0.0004518106,0.0006672775,0.00264671,0.000508707,0.001768509,0.000650394,0.001709183,0.001741663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006701998,"about_ca_system_score_gemma":0.001060885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007080269,"about_ca_topic_score_gemma":0.0007257232,"domain_scores_codex":[0.9995511,0.00004877372,0.00003828863,0.0001188199,0.0002027579,0.00004018193],"domain_scores_gemma":[0.9994734,0.0002574795,0.00005726916,0.00002007025,0.0001613778,0.00003048863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006754096,0.0001228432,0.0003143813,0.02246228,0.00007681736,0.0003451009,0.0001463175,0.0006997287,0.02922386,0.01105377,0.0177435,0.9177438],"study_design_scores_gemma":[0.000009100962,0.0001599059,0.0005252937,0.001376673,0.00008179275,0.001276648,0.0000634498,0.0003643199,0.01411416,0.002182433,0.9798074,0.00003896267],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006348965,0.9926094,0.002036832,0.0003384583,0.0003346839,0.00001344417,0.00002984848,0.00003135943,0.003971024],"genre_scores_gemma":[0.003896635,0.9917979,0.001757351,0.0002738235,0.0001842385,0.00001928421,0.00005672036,0.000006289102,0.002007738],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002711876,"threshold_uncertainty_score":0.009072065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2053873821950114,"score_gpt":0.532067627027426,"score_spread":0.3266802448324146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}