{"id":"W2802350433","doi":"10.3390/ph11020035","title":"Research Progress on Rolling Circle Amplification (RCA)-Based Biomedical Sensing","year":2018,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cape Breton University","funders":"National Natural Science Foundation of China; Huaihai Institute of Technology","keywords":"Rolling circle replication; Deoxyribozyme; Nuclease; Biosensor; Aptamer; DNA; Nucleic acid; Computational biology; Nanotechnology; RNA; Surface plasmon resonance; Biology; Molecular biology; Materials science; Gene; Genetics; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001980755,0.0004132254,0.0008132994,0.0003942378,0.0002757026,0.00009492392,0.0004102456,0.0006888873,0.000007350944],"category_scores_gemma":[0.0003447667,0.0003454513,0.0004561154,0.000717094,0.0008877215,0.000002898597,0.0001626421,0.0006947865,0.00009244656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000978639,"about_ca_system_score_gemma":0.0002913002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001354474,"about_ca_topic_score_gemma":7.034703e-7,"domain_scores_codex":[0.9961324,0.0007972813,0.0006514426,0.001092093,0.0006388723,0.0006878953],"domain_scores_gemma":[0.9980635,0.0001916134,0.0002443647,0.0008514252,0.0003705894,0.0002785055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004111906,0.0001684091,6.77124e-7,0.001392912,0.0001440954,0.00001181958,0.00000224359,1.781758e-7,0.002473449,0.000008051943,0.002141018,0.993616],"study_design_scores_gemma":[0.0001610581,0.0002357529,2.788755e-7,0.002727726,0.0002902772,0.00001809198,0.00000469312,0.00027729,0.03799143,0.00003713852,0.9578685,0.0003877434],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001071846,0.9945592,0.003497489,0.0002389987,0.000172941,0.0009024951,0.0000716077,0.0001323024,0.0003177481],"genre_scores_gemma":[0.007602483,0.9840156,0.005488539,0.0002426,0.001453828,0.00005030719,0.0009399863,0.0001021128,0.0001045857],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9932283,"threshold_uncertainty_score":0.9998997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2053873821950114,"score_gpt":0.532067627027426,"score_spread":0.3266802448324146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}