{"id":"W2802409103","doi":"10.1093/nar/gky313","title":"Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Cancer Society Research Institute; National Cancer Institute; Masonic Cancer Center, University of Minnesota; National Institutes of Health","keywords":"Biology; Proliferating cell nuclear antigen; Genome instability; DNA repair; DNA replication; DNA damage; Histone; Molecular biology; Cell biology; Endonuclease; DNA polymerase delta; Replication factor C; DNA mismatch repair; Eukaryotic DNA replication; DNA; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001456465,0.0001875191,0.0001947112,0.0001606559,0.0002163715,0.0000661493,0.0002880808,0.0002506496,0.000135431],"category_scores_gemma":[0.0004444727,0.0001764839,0.00005709427,0.0001938275,0.000603149,0.0000196657,0.001057366,0.0003569988,0.00008138468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007612358,"about_ca_system_score_gemma":0.00009541019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001057099,"about_ca_topic_score_gemma":0.0001752955,"domain_scores_codex":[0.9973096,0.0005703541,0.0002183018,0.0007881704,0.0005008298,0.0006127243],"domain_scores_gemma":[0.9986902,0.00004459705,0.00003837074,0.000785885,0.0002114706,0.0002294314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003086183,0.000162364,0.002495336,0.00003081374,0.00001384722,0.00003966614,0.0003305072,0.000001047311,0.994296,0.0001483436,0.0001319566,0.00204148],"study_design_scores_gemma":[0.001342276,0.0009057563,0.08633436,0.00005022213,0.000005267954,0.00003095556,0.0008732519,0.0004633344,0.9000435,0.0006116903,0.009013652,0.0003257753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922341,0.00007926501,0.00004004702,0.0001507741,0.00005522906,0.0004210726,0.00003207395,0.00002569373,0.006961793],"genre_scores_gemma":[0.9982516,0.00005860235,0.0006821651,0.00009157178,0.0002158917,0.0000257941,0.00002545606,0.00004061735,0.0006083325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09425256,"threshold_uncertainty_score":0.7196804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02562900177884894,"score_gpt":0.3082299963064546,"score_spread":0.2826009945276057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}