{"id":"W2802422839","doi":"10.1093/nar/gky273","title":"miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5′ end from the cellular pyrophosphatases, DOM3Z and DUSP11","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biology; RNA; Gene knockdown; Pyrophosphatases; Hepatitis C virus; Cell biology; Subgenomic mRNA; Genome; Virology; RNA interference; RNA virus; RIG-I; Genetics; Virus; Gene; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001522842,0.0001872552,0.0002676664,0.00007593017,0.0005474939,0.00003822535,0.0007189686,0.000239496,0.00231562],"category_scores_gemma":[0.0005611378,0.00007706281,0.0001253648,0.0002608011,0.003119683,0.00007495882,0.0004096335,0.0007750316,0.0002351248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004731673,"about_ca_system_score_gemma":0.0001166014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002848545,"about_ca_topic_score_gemma":0.00004740106,"domain_scores_codex":[0.9967753,0.001939626,0.0003406576,0.0002907757,0.0001822165,0.0004714196],"domain_scores_gemma":[0.9979082,0.0008324794,0.0001624852,0.0007331512,0.0003385002,0.00002515315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0020479,0.0001119612,0.0001232623,0.00001371415,0.0002163561,0.000001584712,0.001856809,6.750202e-8,0.987636,0.00004123517,0.003040485,0.004910584],"study_design_scores_gemma":[0.001109657,0.000618383,0.005142933,0.00006111441,0.0000233127,0.000007556733,0.001280586,0.000005486985,0.9663296,0.0003015667,0.02501664,0.0001031729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991941,0.00413209,0.000007324433,0.00127655,0.0001858915,0.0008166504,0.001178871,0.00001294557,0.0004487014],"genre_scores_gemma":[0.9969307,0.0003540595,0.00001076618,0.0001106066,0.00005465072,0.00003280738,0.00005900338,0.00002772816,0.002419709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02197616,"threshold_uncertainty_score":0.9995933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869341969054948,"score_gpt":0.2895988613321853,"score_spread":0.2609054416416359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}