{"id":"W2802422839","doi":"10.1093/nar/gky273","title":"miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5′ end from the cellular pyrophosphatases, DOM3Z and DUSP11","year":2018,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biology; RNA; Gene knockdown; Pyrophosphatases; Hepatitis C virus; Cell biology; Subgenomic mRNA; Genome; Virology; RNA interference; RNA virus; RIG-I; Genetics; Virus; Gene; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001210435,0.0002395532,0.0002923052,0.0001022867,0.0001402305,0.0003965461,0.000192341,0.0002943372,0.001623058],"category_scores_gemma":[0.000199598,0.0001601211,0.000227957,0.00008569832,0.0002198077,0.0002254127,0.0001757059,0.000552311,0.0005193613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002104582,"about_ca_system_score_gemma":0.0001846382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004992092,"about_ca_topic_score_gemma":0.0006081208,"domain_scores_codex":[0.9998015,0.00003169697,0.00002654807,0.00004321337,0.00006378701,0.00003326258],"domain_scores_gemma":[0.9998555,0.00002650965,0.00003641342,0.00002039875,0.0000194567,0.00004161551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001295329,0.00001797489,0.0001139553,0.00003683902,0.000004655013,0.00002069061,0.000005816575,0.00003094011,0.9988287,0.00006719703,0.00003475755,0.0007088945],"study_design_scores_gemma":[0.00001193522,0.0002556121,0.002398783,0.000003370684,0.00001725758,0.0001412007,0.00001750143,0.0007651131,0.9938793,0.00003568083,0.002470074,0.00000407591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915382,0.001779688,0.002818925,0.0001454305,0.00009303185,0.00002534144,0.0006170636,0.0001457523,0.002836747],"genre_scores_gemma":[0.9947436,0.0004941397,0.001507027,0.00008178479,0.000009448957,0.00002516756,0.0006912702,0.00002870757,0.002418813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001623058,"threshold_uncertainty_score":0.005429685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869341969054948,"score_gpt":0.2895988613321853,"score_spread":0.2609054416416359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}