{"id":"W2802429942","doi":"10.1093/molbev/msy085","title":"Neutral Theory, Disease Mutations, and Personal Exomes","year":2018,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. National Library of Medicine; National Institutes of Health; University of Waterloo","keywords":"Biology; Evolutionary biology; Exome sequencing; Exome; Lineage (genetic); Genetics; Molecular evolution; Neutral theory of molecular evolution; Mutation; Phylogenetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002401149,0.0003334752,0.0006936035,0.001507174,0.0009477188,0.001824246,0.0008438734,0.00156472,0.003301394],"category_scores_gemma":[0.006926414,0.0002379559,0.0005365006,0.001164807,0.003796361,0.003872068,0.00138952,0.001346921,0.0002837164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000840772,"about_ca_system_score_gemma":0.0003436418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005594432,"about_ca_topic_score_gemma":0.0004824492,"domain_scores_codex":[0.9987453,0.000480834,0.00005552527,0.0004266336,0.0001899606,0.0001017288],"domain_scores_gemma":[0.9956378,0.002997723,0.0005859002,0.0003486207,0.0001782021,0.0002518225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007472947,0.0001145627,0.07431823,0.0007233212,0.0004048331,0.003472743,0.002452467,0.01293373,0.02394867,0.7637534,0.003823157,0.1133076],"study_design_scores_gemma":[0.00003731859,0.0001074823,0.02708667,0.0001076633,0.00007196303,0.004125703,0.0006373383,0.01443803,0.003045573,0.9372986,0.0129746,0.00006910718],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7200725,0.02393579,0.2069107,0.01371787,0.0005100617,0.00007127252,0.001473248,0.0002663197,0.03304217],"genre_scores_gemma":[0.9738464,0.002912552,0.01843973,0.00160425,0.0002825226,0.00006664822,0.0004315923,0.00004518305,0.002370976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003301394,"threshold_uncertainty_score":0.01269859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005011935475353274,"score_gpt":0.2443375295259606,"score_spread":0.2393255940506073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}