{"id":"W2802505360","doi":"10.1242/dev.162693","title":"The developmental origin of brain tumours: a cellular and molecular framework","year":2018,"lang":"en","type":"review","venue":"Development","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":130,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Neuroblastoma UK; Medical Research Council Canada; Cancer Research UK; Cancer Research UK Cambridge Institute, University of Cambridge; Wellcome Trust","keywords":"Biology; Neural stem cell; Stem cell; Embryonic stem cell; Progenitor cell; Neuroscience; Progenitor; Medulloblastoma; Lineage (genetic); Cancer stem cell; Cellular differentiation; Glioma; Cell biology; Cancer research; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003521944,0.0007102471,0.0009631031,0.002549229,0.0003064586,0.001006271,0.0007729443,0.001126593,0.002908473],"category_scores_gemma":[0.0006224743,0.0002150827,0.0003689349,0.002129203,0.0006378116,0.001744362,0.0007048314,0.001734236,0.00148293],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007219586,"about_ca_system_score_gemma":0.001332314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009514735,"about_ca_topic_score_gemma":0.001528423,"domain_scores_codex":[0.999878,0.00001981894,0.00002105064,0.00002143445,0.00004511985,0.00001437473],"domain_scores_gemma":[0.9997628,0.0001141305,0.00003780028,0.000006311761,0.00005368109,0.00002533921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005119938,0.00004450066,0.0002118223,0.01899632,0.00006057274,0.0004650232,0.0001260678,0.0004783973,0.00232565,0.01067387,0.03376994,0.9327967],"study_design_scores_gemma":[0.000004132025,0.00003617214,0.0004907463,0.003206498,0.00004334815,0.001497923,0.0000660906,0.00004167046,0.0002734506,0.003122574,0.9912061,0.00001131004],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000775873,0.9982667,0.0001251595,0.0004070502,0.0002003223,0.000002493964,0.00001401191,0.000006389895,0.0009003135],"genre_scores_gemma":[0.0004619953,0.9987913,0.0001156617,0.0001462845,0.0001472792,0.00000276767,0.00001549429,9.571036e-7,0.000318348],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002908473,"threshold_uncertainty_score":0.009729803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03399885864776764,"score_gpt":0.3173443513146946,"score_spread":0.2833454926669269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}