{"id":"W2802533205","doi":"10.1128/iai.00208-18","title":"Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency","year":2018,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Amoebic Infections and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Cancer Institute; Government of Canada; National Institutes of Health; Alberta Livestock and Meat Agency; Crohn's and Colitis Canada; Center of Innovation Program; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Paneth cell; Entamoeba histolytica; Mucin 2; Mucin; Biology; Goblet cell; Secretion; Microbiology; Defensin; Mucus; Lysozyme; Ileum; Biochemistry; Gene expression; Small intestine; Epithelium; Antimicrobial; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001625936,0.0001221204,0.0001587648,0.0002216565,0.0003256545,0.00002077173,0.0000160149,0.0000802928,0.0003412768],"category_scores_gemma":[0.00004687883,0.0001062823,0.00003528731,0.0002372398,0.0001978275,0.0001198547,0.00003759962,0.0002384426,0.00006649069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001388112,"about_ca_system_score_gemma":0.0000463839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006046352,"about_ca_topic_score_gemma":0.0006553875,"domain_scores_codex":[0.9993321,0.00007119526,0.0001770409,0.0001740679,0.0000719536,0.0001736159],"domain_scores_gemma":[0.9995713,0.00004686552,0.00004812563,0.000178488,0.00006114243,0.00009402879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000144033,0.001103945,0.9682261,0.00006494386,0.00003909161,0.00001050683,0.001178162,0.000001414351,0.00296723,0.0002087499,0.0006040532,0.02545176],"study_design_scores_gemma":[0.002034378,0.00136398,0.9818776,0.00004114064,0.0000913424,0.0002205226,0.0003624062,0.0002215466,0.001057244,0.0001062579,0.0124878,0.0001357471],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613245,0.0001193667,0.0003222046,0.000089403,0.0003212609,0.0002051923,0.000003879248,0.00005446319,0.03755978],"genre_scores_gemma":[0.9986023,0.0001757121,0.00006552868,0.0001647285,0.000058019,0.00001562526,0.00001863631,0.00000986034,0.0008896063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03727783,"threshold_uncertainty_score":0.9140317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396005592058169,"score_gpt":0.264779965105281,"score_spread":0.2508199091846993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}