{"id":"W2802556167","doi":"10.1128/mbio.01003-18","title":"CRISPR Screen Reveals that EHEC’s T3SS and Shiga Toxin Rely on Shared Host Factors for Infection","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Howard Hughes Medical Institute","keywords":"CRISPR; Host (biology); Shiga toxin; Microbiology; Biology; Virology; Virulence; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003111613,0.0001207332,0.0002791018,0.00009645079,0.0001076489,0.00002291753,0.00005135524,0.0001109492,0.0001568659],"category_scores_gemma":[0.0009841168,0.00009442798,0.00007127358,0.00005969295,0.0001336098,0.00008290914,0.00004488112,0.0001479191,0.00004684729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005329131,"about_ca_system_score_gemma":0.00001452921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004689807,"about_ca_topic_score_gemma":0.0003306731,"domain_scores_codex":[0.998971,0.00007566762,0.0001686186,0.0002743986,0.0001222276,0.0003880546],"domain_scores_gemma":[0.9994128,0.00006372557,0.00005043084,0.0001902187,0.00007065678,0.000212154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001197488,0.00007720499,0.8608927,0.00007613093,0.0000550361,0.000008968789,0.0001331355,7.052484e-8,0.01981662,0.0001064882,0.1145905,0.003045678],"study_design_scores_gemma":[0.001286205,0.0046502,0.9676028,0.0001523211,0.0000174126,0.00001769882,0.0000374344,0.00003828897,0.005472427,0.0001939831,0.02045073,0.00008044202],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994389,0.00004689794,0.0006354771,0.003020055,0.0001559068,0.0005091236,0.00008583739,0.00005139767,0.001106279],"genre_scores_gemma":[0.9959605,0.0001000594,0.0004428101,0.001572664,0.0003515542,0.00003113086,0.0001107432,0.00001848902,0.001412036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1067102,"threshold_uncertainty_score":0.3850661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09545603542502899,"score_gpt":0.3707236829904063,"score_spread":0.2752676475653772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}